The Glasgow Prognostic Score Is An Independent Prognostic Predictor Of Hepatocellular Carcinoma

ObjectiveWe aimed to uncover the correlation between the GPS score pre-operatively and theclinical outcome of HCC patients after radical resection.MethodsThe patients was separate into three subgroups on the basis of the GPS score. Patientswith both an elevated CRP (>10mg/L) and hypoalbuminemia (<35g/L) wereallocated a score of2. Patients in whom only1of these biochemical abnormalitieswas present were allocated a score of1. Patients with neither of these abnormalitieswere allocated a score of0.The prognostic Significance of GPS in the patient cohortwas evaluated by survival analysis.ResultsOn univariate analysis, the level of C-reactive protein, albumin, Child-Pugh, vascularinvasion, tumor number, tumor size, TNM stage, and GPS score were associated withoverall survival and time to recurrence of HCC patients after radical resection. Onmultivariate analysis, tumor size, albumin level, and GPS score were independentlyassociated with the outcome of HCC post-operatively. And GPS score was anindependent prognostic predictor for TTR (P=0.004);ConclusionGPS score is an independent biomarker for prognostic prediction of HCC followingradical resection.