| Objective:Small cell lung cancer(SCLC)has a low 5-year survival rate,and more and more biomarkers have been studied to evaluate the prognosis of cancer patients.Studies have found that inflammatory response and nutritional status affect the survival of tumors.The Glasgow prognostic score(GPS)and the modified Glasgow prognostic score(m GPS)are based on C-reactive protein(CRP)and serum albumin(ALB),which reflect the inflammatory and nutritional status of patients comprehensively.The aim of this study was to evaluate the prognostic value of GPS and m GPS in small cell lung cancer patients.Methods:Patients in Cancer Center of the First Hospital of Jilin University between March 10,2011 and April 30,2017,with small cell lung cancer treated with platinum-containing chemotherapy were included in the study.The clinicopathological features included gender,age,smoking history,ECOG,stage,chest radiotherapy and brain radiotherapy.The χ2test was used to compare the correlation between clinicopathological features and GPS/m GPS.Univariate survival analysis were performed using Kaplan-Meier method.The Cox proportional hazard model was used for multivariate analysis.Analysis was performed using SPSS software.Results:1.In this study,277 patients with small cell lung cancer were enrolled,including 105 patients with GPS 0,172 patients with GPS 1-2,116 patients with m GPS 0 and 161 patients with m GPS 1-2,respectively.2.Clinical stages were correlated with GPS/m GPS,but gender,age,smoking history,ECOG,chest radiotherapy,craniocerebral radiotherapy were not correlated with GPS or m GPS.3.Univariate analysis showed that clinical stage,chest radiotherapy,craniocerebral radiotherapy,GPS and m GPS were related to progressionfree survival,while gender,age,smoking history and ECOG were not related to progression-free survival.4.Multivariate analysis showed that m GPS 1-2 scores(HR: 1.303,95%CI: 1.001–1.696,P=0.049)were significantly correlated with PFS reduction.5.Univariate analysis showed that clinical stage,chest radiotherapy,craniocerebral radiotherapy and m GPS were related to overall survival,while sex,age,smoking history,ECOG and GPS were not related to overall survival.6.Multivariate analysis showed that m GPS 1-2 scores(HR: 1.418,95%CI: 1.071–1.878,P=0.015)were significantly correlated with OS reduction.Conclusion:1.m GPS is an independent prognostic factor for PFS and OS in patients with small cell lung cancer receiving first-line chemotherapy with platinum-containing double-drug chemotherapy.The PFS and OS in patients with m GPS score of 1-2 are shorter.2.GPS is not an independent prognostic factor for PFS and OS in patients with small cell lung cancer receiving first-line chemotherapy with platinum-containing double-drug chemotherapy.3.Compared with GPS,m GPS is more valuable in evaluating the prognosis of small cell lung cancer. |
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