The Correlation Between Heart Rate Circadian Rhythm And Glomerular Filtration Rate In Essential Hypertensive Patients

Objective To investigate the association between24h heart rate(HR)circadian rhythm changes and Glomerular Filtration Rate(GFR) in essentialhypertensive(EH) patients.Methods A total of347EH patients without previous treatment underwent24h ambulatory blood pressure monitoring.According to BP or HR decreasedmore than10%or not in nighttime compared to those in the daytime，patientswere divided into two groups: dipper HR、nondipper HR， Comparing thechange of GFR in two group patients.Rusults Non-dippers in HR was32.7%of all the subjects.The GFR meanvalue of nondipper HR group is lower than that in dipper HRgroup(100.64±27.92to110.80±25.52ml/min，P<0.05). After correctingall the factors， The GFR of nondipper HR group is still lower than thatin dipper HR group (102.45±2.33to109.02±1.73ml/min，P<0.05).Singlefactor partial correlation analysis show that nondipper HR is negativelycorrelation with GFR(r=-0.132，P=0.029).Conclusion Heart rate circadian rhythm change is correlation with GFRin EH patients.