The Correlation Study Between Radio Sensitivity Of Human Nasopharyngeal Carcinoma And Nutritional Status

[Objective]To assess the integrated nutritional status of patients with nasopharyngeal carcinoma, and explore the relationship between nutritional status and radiosensitivity. To provide the theory basis and the practical operation method for clinicians to predict the radiosensitivity.[Methods]Patients who were primarily diagnosed as nasopharyngeal carcinoma were enrolled in this study in First Affiliate Hospital of Fujian Medical University from September,20011to December,2013. The demographic data, clinical informations and nutritional status were collected by trained interviewers with self-constructed questionnaires. WHO solid tumor response evaluation criteria was used to assess recent effect. Influencing factors of radiosensitivity were analyzed by Independent-samples t test, chi-squared test Fisher test and unconditional Logistic regression. A nutrition index model(NI) was built to assess the nutritional status by principal components analysis. The effect of NI on radiosensitivity was analyzed by Logistic regression. ROC curve was used to analyze the nutritional index. Influencing factors of nutritional status were analyzed by paired t-test and the multiple stepwise regression.[Results]1. There were160(78.8%) persons were sensitive to radiotherapy and43(21.2%) persons were not sensitive during all the203patients.2. Univariate analysis showed that there was significant difference in the arm circumference, albumin, hemoglobin, prealbumin and transferrinnutrition. The t values were2.058,3.811,3.308,3.567,2.557, and p values were0.041,＜0.001,0.001,＜0.001,0.011. The nutritional indicators of radio-sensitive group was higher than radio-insensitive group.3. Multivariate Logistic regression analysis performed T stage and integrated nutrition index were independent factors affecting radiosensitivity.4. ROC curve analysis demonstrated that the optimal cut-off point was5.83. The sensitivity and specificity were0.850and0.465.5. All nutritional indctors declined after radiotherapy. Paired t-test analysis performed that the difference was was statistically significant. Multiple stepwise regression analysis performed that influencing factors of nutritional status were acute radiotoxicity, age, income.[Conclusion]1. History of chronic illness, T stage and nutritional status were the influencing factors of radiosensitivity in human nasopharyngeal carcinoma.2.The bad nutritional status was significantly associated with bad nasopharyngeal carcinoma radiosensitivity, and may become an important indicator to predict the radiosensitivity.3. Our suggestion is that patients whose nutrition index is less than5.83should be given nutritional support, while the others could not.4. Nutritional status in patients with nasopharyngeal carcinoma decreased significantly during radiotherapy. Radiotoxicity is the factor of treatment related to nutritional status. The results suggest that in order to improve the nutritional status of the patients and improve the curative effect of radiation，clinical attention should be paid to the monitoring of patients’ radiotoxicity and adjusting the treatment plan timely and taking symptomatic treatment, dietguidance and tother nutritional interventions for patients is necessary.