Adenomyosis Dysmenorrhea Related Inflammatory Mediators And Related Clinical Characteristics Analysis

Objective: To investigate the relationship between adenomyosis dysmenorrhea and inflammatory mediators and clinical characteristics.Methods: The people’s Hospital of Fujian traditional Chinese Medicine University in2011October~2012October for adenomyosis undergoing laparoscopic hysterecto-my in100cases, all patients were treated with laparoscopic operation treatment, including54cases of laparoscopic total hysterectomy, laparoscopic subtotal hyste-rectomy in46cases, and by postoperative pathological diagnosis. According to the preoperative degree of dysmenorrhea were divided into4groups, the group of painless, mild dysmenorrhea dysmenorrhea group, moderate group, severe dysme-norrheagroup. Compared with no symptoms of dysmenorrhea uterine fibroid-s patients undergoing operation for treatment of100cases as control grou-p. Analysis of dysmenorrhea and uterine size, serum CA125, IL-6, PGF2a and sPLA2in peritoneal fluid determination of relationship value. Follow-up andre-trospective analysis of the recovery operation and postoperative1-6months.Results:1. Adenomyosis group compared with the average age of the group ahead of uterine fibroids6years.2. Serum CA125values adenomyosis (AM) group (125.62±20.34U/ml), was significantly higher (15.91±11.52U/ml)(P<0.05), and showed a positive correlation with the size of the uterus (P<0.05). Interleukin-6(IL-6), peritoneal fluid prostaglandins (PGF2a), phospholipase A2(sPLA2) in the AM group (52.23±4.93pg/ml,83.43±5.93ρ/pg mg-1,76.34±5.34u/L,) the control group (15.23±6.07pg/ml,33.64±5.95,34ρ/pg mg-1,42±11.32u/L)(P<0.05), the degree of positive correlation with dysmenorrhea (P <0.05). 3. Satisfactory hysterectomy can relieve symptoms of dysmenorrhea recently, but subtotal hysterectomy compared with total hysterectomy more favorable postope-rative recovery.Conclusion:1. Adenomyosis pain and endogenous inflammatory cytokines IL-6, PLA2, PGF2a.2. Dysmenorrhea is the main reason for the patients with surgical treatment, hys-terectomy surgery to relieve pain symptoms effectively in the near future.