Clinical Significance Of P53Protein, Ki67Antigen And CDX2Protein Expression In Gastric Carcinoma Tissues

Objective: To study the expression of P53Protein, Ki67Antigenand CDX2Protein in human gastric carcinoma(GC),and analyze the relationof the three parameters to biological behavior and prognosis.Methods: Tissue samples from120patients treated by gastricresection for GC were used.The expression of P53protein, Ki67antigenand CDX2protein were detected immunohistochemically. The results werecorrelated with clinicopathological features and prognosis. Astatistical analysis was made according to the pathological datus.Results:(1) Positive expression rates of P53Protein, Ki67Antigenand CDX2Protein were47.5%,80.0%and58.3%respectively.(2) P53protein expression were correlated with differentiationdegree,distant metastasis， depth invasion， TNM stage， lymph nodemetastases and Laurén classification (P＜0.05), and was not correlatedwith age, gender, tumor location, and size.(P＞0.05)．(3) Ki67expression were correlated with tumor differentiation degree，depth invasion,lymph node metastasis and Laurén classification (P＜0.05)．(4) The positive expression of CDX2were correlated with tumor TNMstage，differentiation degree，depth invasion，and was not correlated withage, gender, tumor location, size and lymph node metastasis. CDX2expression was also markedly different between intestinal-type GC anddiffuse-type GC(74.2%:38.9%,P<0.001).(5) The positive correlation was present between P53proteinand Ki67antigen.(r=0.184,p＜0.05). (6) The Ki67antigen expression in gastric carcinoma was negativelycorrelated with the CDX2Protein expression(r=-0.254,p＜0.05).(7) The positive expression of CDX2was’t correlated with the P53proteinexpression(p<0.05).Conclusions: The P53protein expression, Ki67antigen expression andCDX2protein expression in gastric cancer were high,and they were highclinical significance for judging the depth invasion, malignanct andprognosis of gastric carcinoma.