Retrospective Study: Etiology Of Recurrent Acute Pancreatitis And Correlation Analysis

ObjectivesTo evaluate patients with recurrent acute pancreatitis etiology and clinical features.MethodsStudy73cases of recurrent acute pancreatitis among patients with acute pancreatitis in Fujian Provincial Hospital data, analyzing the causes and associated clinical characteristics of patients with recurrent acute pancreatitis.Results①Etiology:73cases of patients with acute recurrent pancreatitis, gallstone RAP29cases (39.7%), hyperlipidemia of RAP accounted for23cases (31.5%); alcoholic AP accounted for8cases (11.0%); eating properly accounted correlation RAP5patients (6.8%); there are eight cases (11.0%) of the RAP for other less common causes, have split pancreas, pancreatic duct is too long, ERCP surgery, congenital bile the lower duct stenosis, duodenal papilla cancer, idiopathic pancreatitis. With the same period of hospitalization compared with the initial issuance of AP, a higher proportion of hyperlipidemia group (31.5%), while a lower proportion of gallstone group (39.7%), compared to other factors, the difference was not statistically significant (P>0.05).②Etiology and Gender: male ratio RAP alcohol than women (X2=18.96, P <0.005), whereas women constitute more than other groups no significant difference (P>0.05). Male and female risk factors are biliary, alcoholic, accounting for38.9%(40.5%),38.9%(24.3%), respectively.③Etiology and age: the average age of onset of the initial RAP patients was46.6±19.2years (11-90years old); average initial age of onset biliary and hyperlipidemia group RAP higher than the other groups were54.93±19.79,46.22±17.15(years old), and in addition to biliary and hyperlipidemia cause of RAP rest grouping average initial peak age of onset was no significant difference (P <0.05).1to29years,30to64years,64to99 years old in three age groups,65to99-year-old patients with biliary RAP factors higher proportion of the other two age groups (69.2%, P <0.0125), and0to29years of RAP patients with improper diet dominated (33.3%), and the other two age groups was statistically significant.④Etiology and episodes: In this study, there are a number of RAP relapse to6times, average1.79times/person, which recur over three times and all male patients accounted for the majority (8/10,80%), including4cases of alcoholic RAP,2cases of elderly cholelithiasis, one case of congenital biliary malformations, one case of pancreatic duct abnormalities in patients; history of RAP within two years accounted for78.08%recurrence recalled.⑤Disease etiology and prognosis: severe acute pancreatitis (SAP) accounted for19.2%, there was no significant statistical difference between the groups in the etiology of disease severity caused by RAP grading (P>0.05); In73RAP patients,59cases of conservative treatment,6treated with medical and surgery，8with routine conservative and endoscopic treatment. Of which12cases were cured, improved in57cases,4cases unhealed (to give up treatment, discharged).Conclusions1.Cause of acute recurrent pancreatitis constituted mainly biliary and hyperlipidemia, followed by alcohol.2.RAP alcoholic male-dominated, and the remaining proportion of men and women in each group causes no significant difference.3.65years of age or older RAP factor in the pathogenesis of biliary based.4.Occurred in patients with SAP, RAP may not significantly associated with the cause.5.Currently, most patients with RAP through comprehensive treatment can achieve better efficacy, but should pay attention to the prevention of relapse treatment for the cause.