Arterial Stiffness In High Altitude Area Comparative Analysis Between Different Diseases

Objective: To research analysis of arterial stiffness variation between differentdiseases at high altitudes, and further draw the relationship between arterial stiffnessin patients with essential hypertension and diabetes.Method: The study is mainly choose high altitudes (more than2280meters above sealevel) in patients with essential hypertension and diabetes each100cases and100healthy volunteers, respectively, as the hypertension group and diabetes group, as wellas health groups, and related information collected clinical data. The application fullyautomatic arteriosclerosis detector vP a1000determination of brachial-ankle pulsewave velocity (braehial off ankle pu1Se wavevelocity baPWV) reaction in patientswith peripheral arterial stiffness, and all enrolled patients were measuredbrachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI) and carotidintima-media thickness (IMT). All included patients will be asked to smoking, as wellas a history of diabetes and blood pressure measurement. Venous blood collected afterthe patient is admitted to hospital, followed by fasting8-12hours after biochemicaltests, measurement of fasting blood glucose, total cholesterol (TC), creatinine, andglycated hemoglobin statistics by comparing the test data, comparative analysis ofbaPWV ABI and IMT in the relationship that exists between the different diseases,and to understand the patient’s arterial stiffness in the relationship between thedifferent diseases. The research data were analyzed using SPSS15.0analysis withdose for normally distributed data (mean±standard deviation) said that thedifferences between the groups using t test, P <0.05difference statistically significant.Results: Derived by the analysis of the experimental results, The essentialhypertension baPWV average （2368.4±207.2）cm/s, ABI was （0.63±0.18）; IMTwas（1.29±0.12）mm， The diabetic group baPWV average （1927.6±224.2）cm/s,ABI was(0.93±0.09); IMT was（1.04±0.11）mm， Health of the baPWV the group average （1212.8±137.1）cm/s, ABI was (1.09±0.12), and the diabetic group andhypertension group baPWV were higher than the healthy volunteers group differencesbetween each group has a statistically significant (P <0.01); Between diabetic andhypertensive significant sex difference was statistically significant (P <0.01).Conclusion: The experimental data of the survey showed that in patients withessential hypertension and diabetes, arterial stiffness difference was statisticallysignificant (P <0.01). Essential hypertension group baPWV and IMT indicators thanthe diabetic group compared, showing an increasing tendency, so serious hypertensivepatients with arterial stiffness than diabetes. High altitudes existing high altitude, lowoxygen, and air pressure and low environmental factors, as well as a special eatinghabits, heavier patients with arterial stiffness degree of stenosis in the carotid intima,promote the patients due to unstable plaque formation. PWV is a safe, simple,non-invasive detection method can effectively detect the degree of patients witharterial stiffness, the predictive value of different diseases between the high altitudes.