The Study Of Free HCV Core Antigen Test’ Value In Early Screening And Early Treatment With Different Genotypes For Hepatitis C

Objective We detected the specificity,sensitivity and effectively of HCV core (free) antigen ELISA test,and validated the test’s function in reducing the HCV window period.We discussed the consistency between HCV core (free) antigen detection and HCV RNA detection.We compared the statistical differences of EVR between the risk factors’ group treated by different genotypes whose HCV RNA and HCV core (free) antigen dectection were positive, and HCV elisa detection were negative and the matched group treated by different genotypes whose HCV RNA positive dectection were positive,HCV core (free) antigen dectection were negative, and HCV elisa ware positive.Methods We compared the test results of HCV RAN and HCV (free) core antigen between300cases of normal physical examination population group and35patients with HCV infection determined by follow-up who had risk factors. Population groups with risk factors had a exposure history of many contacts with HCV infection.And we compared EVR after treatment of12weeks through the "guidelines on the prevention and treatment of hepatitis c" between35patients with HCV infection who had risk factors and40cases treated matched group of patients with chronic course of HCV infection in more than one year. All patients were excluded from other hepatitis virus infections, and the same time did not receive antiviral treatment.Results One case(0.33%) had HCV core antigen positive results in300cases of normal physical examination group whose HCV RAN and HCV (free) core antigen detection were negative.33case(94.29%) had HCV core antigen positive results in35cases of confirmed HCV infection when the time was initial detection.In comparison of HCV core antigen assay and HCV antibody assay,the window period of HCV was shortened by about34-36day.HCV-core antigen HCV ELISA method compared with an average reduction of window period of about34-36days. EVR P-value in genotype1patients between risk factors group and matched group was<0.01, and this prompted a statistically significant difference. Fisher precise inspection precision Sig.(unilateral) was<0.05in genotype2(non-genotype1) patients between risk factors group and matched group,and this prompted a significant difference.Conclusion HCV core (free) antigen ELISA test has good specificity and sensitivity. HCV core (free) antigen test can effectively reduce the window period of HCV detection. HCV core (free) antigen and HCV RNA test are in good consistency. EVR of patients with risk factors group whose HCV RNA test was positive, HCV (free) core antigen was positive and Anti-HCV was negative in genotype1and genotype2(non-genotype1) are higher than EVR of matched patients whose HCV RNA test was positive, HCV (free) core antigen was negative and Anti-HCV was positive. HCV core antigen experiments can be used as an effective supplement to hepatitis C detection testing.