Effects Of Sodium Butyrate Supplementation On Immunity And Its Antioxidant Functions In Transition Cows And Neonatal Calves

This thesis consists of two parts, the first part of the experiment to study the effect of sodium butyrate inthe diet of prpartum on antioxidant capacity and immune of transition cows. The second part of theexperiment was designed to research the effects of dietary supplementation of sodium butyrate in the diet ofprepartum on calf birth weight and body size, antioxidant capacity, immunity.45prepartum Holstein dairycows with same body weight, parity, milk yield in the last lactation as well as the expected date of calvingwere blocked and assigned randomly to three groups, each group with15cows supplemented with differentlevels of sodium butyrate(control group, only fed the basal diet without an supplementation; group1, basaldiet+200g/d of sodium butyrate(1.5%DM); group2,basal diet+400g/d of sodium(3%DM). The experimentstarted from21d before calving and ended28d after calving, the new born calves from3groups wereselected to determine the effect of supplementation of sodium butyrate on immunity and its antioxidantfunctions in calves. The results showed that:The superoxide dismutase level（SOD） in the group1(200g/d adding group) was15.4%higher thanthat group2(400g/d adding group)(P <0.01), while total antioxidant capacity group2(400g/d addinggroup)increased by138.1%(P <0.05) compared with control group7days before calving, SOD content ingroup1(200g/d group) was improved by14.0%compared with control group in14d postpartum. Theglutathione peroxidase levels in group1(200g/d adding group) increased10.1%(P <0.05) than group2(400g/d adding group) in postmartum21d.Compared with the control group24h after calving, the glutathione peroxidase levels of group1(200g/d adding group) and group2(400g/d adding group) in newborn calves increased1.41%and9.9%(P<0.05), respectively. In48h after calving, glutathione peroxidase levels in group1(200g/d adding group)and group2(400g/d adding group) decreased13.9%and7.85%compared with the control group(P<0.05).The results showed that200g/d of sodium butyrate improve the antioxidant capacity effect better thanadding400g/d. Supplement on sodium butyrate on transition cows had little effect on neonatal calves.