Study On Lipid Metabolism Disorder Animal Models Regulated By The Capsules Of Rhizoma Alismatis Compound

Objective:To investigate the effects of Compound Rhizoma Alismatis Capsule (CRAC) on the on prevention and treatment of lipid metabolism disturbance and hepatic adipose infiltration by the animal models, in order to provide pharmacodynamics experimental basis for the further research of group recipe.Methods:Animal models with lipid metabolism disturbance and hepatic adipose infiltration were established with high fat emulsion by lavage in mices and high fat fodder by feeding in rats, rabbits and quail. Then observe the effects on animal lipids and other biochemical indicators.Result:1、The result of prophylactic administration of lipid metabolism in mice experiments showed that Compound Rhizoma Alismatis Capsule (health and drug content) of 20 g/kg.bw dosage,50 g/kg.bw dosage、100g/kg.bw g/kg.bw dosage all reduced the levels of serum TC, 100g/kg.bw dosage group also reduced the serum levels of TG.2、The result of dyslipidaemia in rats administered treatment experiments showed that Compound Rhizoma Alismatis Capsule (health and drug content) of 25.4g/kg.bw dosage and 36.3g/kg.bw dosage, both played a role in regulating lipid metabolism.3、The result of prophylactic administration of fatty liver in rat experiments showed that Compound Rhizoma Alismatis Capsule (health and drug content) of 17.8g/kg.bw dosage、25.4g/kg.bw dosage and 36.3g/kg.bw dosage reduced the serum levels of TC、the levels of cholesterol in liver tissue and the levels of MDA significantly in the fatty liver of rats.4、The result of dyslipidaemia in rabbits administered treatment experiments showed that Compound Rhizoma Alismatis Capsule (health and drug content) of 9.3g/kg.bw dosage,13.3g/kg.bw dosage and 19.0g/kg.bw dosage all had no significant effect on rabbits lipids.9.3g/kg.bw dosage group and 19.0g/kg.bw dosage group increased the serum levels of NO.13.3g/kg.bw dosage group increased the serum levels of GSH.5、The result of dyslipidaemia in quails administered treatment experiments showed that 17.8g/kg.bw dosage、25.4g/kg.bw dosage and 36.3g/kg.bw dosage reduced the serum levels of TC、the serum levels of TG、the serum levels of MDA、the serum levels of NO.The three dosages all reduced the role of AI significantly and increased the serum levels of SOD. High dosage group、middle dosage at 4th week and high dosage group at 9th week can reduced the serum levels of LDL-C.Low dosage group at 4th week and middle dosage group 9th week increased the the serum levels of, a HDL-C,reduced the level of TC、TG in liver tissue and reduced the the serum levels of ALT, AST.Conclusion:Compound Rhizoma Alismatis Capsule has the effect on regulating blood lipids, preventing lipid peroxidation, reducing the loss of vascular endothelial cells, removing oxygen free radicals, as well as it plays a role in hepatoprotective effect.