Epidemiological Investigation And Diagnosis Of Chronic Fluorosis Of Sheep

In rencent two years a large number of sheep disease in Xinchengzi town of Yongchangcounty Jinchang city, Gansu province. For a detailed understanding of the disease, and for theprevention in the region to reduce economic losses. a field investigation in more serious threevillages was conducted,the fluoride content of the external environment in the area of animalserum, bones, teeth were measured, made a routine blood test and blood biochemistryexamination.The results are as follows:The clinical symptoms of slow growth, weight loss, rough hair disorder,adult ewesrepeated with infertility, miscarriage,stillbirth occurred when they were pregnant, afterdrinking water and grazing they appeared loss of teeth. autopsies found sheep appeareddiarrhea, bronchitis,pneumonia, hepatonecrosis and enterorrhagia, loss of normal teeth enamelgloss, tawny streaks, and the formation of a dent, even gums were polished, molars had tartargenerally, molars were attrited, cracking and other symptoms.As the survey results showed, The prevalence of sheep was as high as82.73%, and themortality and elimination rate was also extremely high at19.27%, and the proportion ofabortion and nonpregnant were13.70%and27.78%respectively, and the proportion Dentalfluorosis was91.8%,and the dental fluorosis index was1.91. In the determination of thefluoride content in body, the fluoride content in the teeth increased very significantly, about10times of that in normal sheep teeth; the fluoride content in the bone was significantlyhigher than1200μg/g, namely the critical value of fluorosis; compared with the control group,the fluoride content in the serum and wool of the sick sheep group increased verysignificantly(P﹤0.01). In the determination of fluoride content in external environment, thefluoride content in water was more than1.0mg/g; compared with the control group, thefluoride content in the soil and grass went up significantly.In the blood physiological and biochemical determination, compared with the controlgroup, the test results of sick sheep were as follows: the total number of RBC reducedsignificantly(P﹤0.05), the HGB and the MCHC reduced very significantly (P﹤0.01), theMCV increased very significantly(P﹤0.01), WBC reduced very significantly(P﹤0.01), the PLT increased significantly(P﹤0.05), and the PCT increased very significantly(P﹤0.01). thevalues showed that calcium and magnesium tended to reduce within the normal range, whilephosphorus increased significantly (P﹤0.05), which was higher than normal standard,alkaline phosphatase and glutamate pyruvate transaminase increased significantly(P﹤0.05),glutamic oxalic transaminase tended to increase, and creatinine increased very significantly (P﹤0.01).