Research Of The Synthesis Of Quinazoline, Acylindole Compounds

Nitrogen heterocyclic compound usually has a unique biological activity, low toxicity, high systemic, is an important bioactive molecules, playing significant role in medicine industry, fine chemical engineering fuel sensitization solar cells and catalytic material on various aspects plays an important role, recently years, its reported continously, the demand of them is growing in all walks of life, such as 3-acyl indole derivatives exhibit a wide range of biological activity:antitumor activity, anti-inflammatory action, as the cytosol phospholipase inhibitors and plant bacteriostasis reported in recent years, quinazoline can be used to fight malaria, antispasmodic, anti-inflammatory, antibacterial and anti-inflammatory.Based on the important application of nitrogen heterocyclic compounds, this thesis emphatically studied the new synthesis methods of these two kinds of nitrogen heterocyclic compounds of quinazolines and acyl indoles, And obtained the following results:Chapter 2 depicted a new synthesis of imidazole quinazolines,Optimizing it’s reaction conditions, obtaining an imidazo[1,2-c]quinazoline compound with the yield of 99%. Using2-(2-nitrophenyl)-1H-benzo[d]imidazole and benzyl alcohol as raw materials,filtrating appropriate catalyst solution、molar ratio and temperature, using column chromatography obtaining reaction result which are verified through the hydrogen and carbon spectrum. Optimal condition:toluene as solvent in 120℃, interacting 24 hours with Pd/C as catalyst, the molar ratio of 2-(2-nitro phenyl) 1 h-benzeneimidazole、benzyl alcohol and catalyst is 1:5:0.02. Chapter 3 depicted a new synthesis of 3-acylindole derivatives, this thesis invented a new route which is economics simple and needs mild reaction conditions、simple operation steps, to obtain high yield of 3-acylindole derivatives. We use nitro define and 2-(2-pyridyl) 1 h-indole as raw materials, Choose CeCl3 as catalyst, and let them react in the ethanol solution for 12 hours then we get a 3-Acylindole compound with high yield of 90%, next, we try to make a validation of the of the reaction applicability by changing the raw material’s type which are all work well, their yields varies from 45% to 98%.