Synthesis Of Metal Iridium Complex And Its Application In Photodynamic Therapy

Due to excellent photo-physical properties iridium complexes performed(large Stocks shifts, tunable UV-vis absorbance and emission, high quantum efficiency and long phosphorescence lifetime), iridium complexes acted as bio-imaging probes have drawn much attention by researchers worldwide. In this thesis, we designed and synthesized a serial iridium complexes, and studied their application in bio-imaging and photodynamic therapy. The work was divided into three parts: 1. Metal iridium complexes for photodynamic therapyWe designed and synthesized two different ligands iridium complexes, and confirmed their structure by 1H NMR, 13 C NMR and MODI-TOF. The photophysical properties of iridium complexes were characterized by UV-vis, phosphorescent spectra and phosphorescent lifetime. We used DMA as specialty of singlet oxygen to detect the production ability of singlet oxygen under >450 nm light. The results show that N^N ligands have great effect on the UV-vis and emission properties of iridium complexes, especially in photodynamic effect property. 2. 730 nm laser driven photodynamic therapy of iridium complexesIn the research of visible light induced photodynamic effects of iridium complexes. We intended to use the poly-pyrrole nanoparticles which shows good absorption properties in near infrared region. Through energy transfer, it can trigger the photodynamic effect of iridium complexes, so as to achieve the treatment of near infrared dynamic thoughts. Interestingly, we found that the iridium complexes can be induced by 730 nm continuous wave laser to generate singlet oxygen. Therefore, we studied the photophysical properties, photodynamic effect in vitro, mechanism of generation of singlet oxygen and its application in animal tumor model. The reason of 730 nm laser driven photodynamic therapy of iridium complexes was due to the nonlinear absorption property of iridium complexes. In the photodynamic therapy treatment of tumor, we observed the photodynamic therapy in histological stain, although the treatment was not obvious due to the low 1O2 quantum efficiency.