Distribution Of Norepinephrine β Receptor In Medial Prefrontal Cortex And Almond Basal Lateral Nucleus Of Mice

Noradrenaline (NA) acting via β-adrenoceptors (β-ARs) in the central nervous system (CNS) plays an important role in learning/memory and cognitive functions. β-ARs have been shown to be expressed in cortical and subcortical principal cells. However, little is known about β-ARs distribution in different types of GABAergic neurons. Here, we reported that both β1- and β2-ARs were expressed in a majority of GABAergic interneurons in the medial prefrontal cortex (mPFC) and basolateral nucleus of amygdala (BLA) of mice, including parvalbumin (PV)-, calretinin (CR)-, calbindin D-28k (CB)-, somatostatin (SST)-, and Reelin-immunoreactive (ir) interneurons. In mPFC, Relative to PV-, CB-, SST- and Reelin-ir interneurons, CR-ir interneurons were less likely to express β1- and β2-ARs. Furthermore, Reelin-ir interneurons in the deep layers were more likely to express β1- and β2-ARs than in the superficial layers. In BLA, PV-ir interneurons are more likely to co-stained with β1-AR than CR-ir ones, and β2-AR was more possible to be found in SST-ir interneurons than in CR-, CB-, and Reelin-ir ones. The present results are of importance for understanding the roles of β-ARs in mPFC and BLA functions.