| This work aimed at clarifying the fole of prefrontal α2-adrenergicantagonist yohimbine was locally infused into the prefrontal cortex(PFC) of rats and monkeys. The results were as follows: 1) the rats(4-, 6-, 8-, and 10-week old) showed a significant increase inhorizontal and vertical activity inopen-fieldafter intra-PFC infusionof yohimbine. The effect of yohimbine was dose-dependen. 2) Weh yohimbin was infused, by using osmotic pumps, intobilateral PFC, the monkeys showed hyperactivity in their homecages, Meanwhile, the monkeys showed a deficit in NO-GOperformance (withdrawing a touching movement when a green visual signal was presented). These results suggest that α2-adrenoceptors in the prefrontal cortex play an important role inbehavioral inhibition. |
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