Simulation Research On The Effect Of Purkinje Fiber On Ventricular Electrical Conduction

Modeling and simulation research of the heart is a novel interdisciplinarysubject. The researchers need to use the combination of Mathematics, computer,cardiac anatomy, Biophysical and many other disciplines to model and simulate thestructure and function of the cardiac. Then analyze and explain the pathophysiologyproblem of clinical medicine and correlated domains based on the simulation results.Whether from modeling to simulation or from methods to technical this subject is ahighly complex and challenging work.Purkinje fiber is an important part of the system. Purkinje fiber plays animportant role in ensuring the synchronized timing and sequencing of ventricularcontraction. There are great differences in action potentials between the Purkinjefiber cell and ventricular muscle cell. In many conditions, Purkinje-Ventricularjunction is considered as the source of serious ventricular arrhythmia. In recentyears, Purkinje fiber becomes a research focus to domestic and internationalexperts.Firstly, an idealized2D computational model of ventricular electricalconduction which contains Purkinje fiber is established to simulate the excitationconduction in the cardiac tissue. And analyze the effects of electrical conductionsystem on heart rate base on pseudo ECG of ventricular tissue. Simulated resultsshow that Purkinje fiber cells can generate the conduction of electric excitation intachycardia and also can suppress excitations in externly slow or fast rhythm.Purkinje fiber plays an important protective role to keep ventricular tissues innormal rhythm.Secondly, Combined with electrical excitation conduction rate and the safetyfactor do some research exploringly to analyze the impact of the width of Purkinjefiber on ventricular conduction system based on the computing model that isproposed in this paper. Simulated results show that the stimulation strength hasalmost no effect on electrical excitation conduction and the driving ability ofPurkinje fibers increases along with the increase of the Purkinje fiber’s width.Finally, this model not only provides a new method to research the mechanismof arrhythmia and can be used to study arrhythmia induced by congenital genemutations and effects of antiarrhythmic drugs, but also further studies on Purkinje-Ventricular coupling junction. The subject of this work has great theoretical andpractical significance.