Effect Of Exercise On Testosterone Biosynthesis Under Different Obese In The Testicular Tissue Of Rats

Objective:It is prevalent that most obesity male individual different degree of exists sexual developmentslow reproductive features low male hormone level reduced symptoms but its role of molecularmechanism is not completely Qing and movement is recognized best reduced body fat of methodwhile on male hormone level also has must of regulation role but for different obesity degree ofindividual whether also has not as of regulation role also not clearly. This research through ondietary induced big rat appeared different obesity State and on its imposed7week of movementintervention discussion movement on high fat dietary induced of different obesity degree malebig rat testicular organization testosterone of biosynthesis of effects aimed at stated obesity andmovement effects testosterone biosynthesis of mechanism for control obesity male hormonelevel low and movement regulation male hormone level provides theory.Methods:1. All of the80SD rats are fed with high-fat fodder for8weeks from which the die-inducedobesity rats and obesity-resistance rats.2. group intervention: after the success modeling ofobesity rats and obesity-resistance rats the rats are divided into6groups: Group DIO DIO+EXCON CON+EX DIO+R and DIO+R+EX. All rats are fed with high-fat diet and meanwhile therats in Group EX are trained to swim.3.7weeks later all the rats are killed and their weight fatmass body fat rate blood testosterone and related protein expression level of testosteronebiosynthesis are measured.Results:1. After15-week high-fat diet and exercise: at the end of the experiment compared with those ofrats in Group CON the weight fat mass and body fat rate of the rats in Group DIO haveincreased dramatically（P<0.01） their blood testosterone has decreased dramatically（P<0.01）;the weight of the rats in Group EX has lowered dramatically（P<0.01）and the blood testosteronehas increased remarkably（P＜0.05）; the weight of the rat in Group DIO+R has lowereddramatically（P<0.01）and their fat mass has decreased remarkably（P＜0.05）; compared withthose of rats in Group DIO the weight fat mass and body fat rate of the rats in Group DIO+EXhave decreased dramatically（P<0.01） their blood testosterone has increased dramatically（P<0.01）. Other indicators are inclined to rise or fall but they haven’t shown any dramaticchange.2. SF-1protein: rats compared with the CON group, DIO Group significantly reduced proteinexpression (P<0.05), protein expression significantly higher CON+EX Group (P<0.05); ratscompared with DIO group, DIO+EX group and a significant increase in protein expression (P<0.01), compared with the DIO+R Group, DIO+R+EX group of protein expression levelssignificantly higher (P<0.05).3.P450scc protein: rats compared with the CON group, DIO Group significantly reduced proteinexpression (P<0.05), protein expression significantly higher CON+EX Group (P<0.05); ratscompared with DIO group, DIO+EX group and a significant increase in protein expression(P<0.05), compared with the DIO+R Group, DIO+R+EX group of protein expression levelsmarkedly elevated (P<0.05).4.StAR protein: rats compared with the CON group, DIO Group significantly reduced proteinexpression (P<0.05), protein expression significantly higher CON+EX Group (P<0.05); ratscompared with DIO group, DIO+EX group and a significant increase in protein expression(P<0.01), compared with the DIO+R Group, DIO+R+EX group of protein expression levelssignificantly higher (P<0.05).Conclusion:1. There of obese rats induced by high fat diet "in patients with low testosterone" and Leydigcells regulate testosterone biosynthesis enzymes related to SF-1,P450c and expression of StARprotein was inhibited.2. Long-term aerobic exercise increases fat obese and obesity resistant rats rat Leydig celltestosterone biosynthesis protein expression of key enzymes in SF-1,P450scc and StARpromoting testosterone biosynthesis and increases serum testosterone levels.