Professor Dong Zhenhua Treatment Of Connective Tissue Disease Combined With Lung Disease Experience

[Background]Connective tissue disease combined with interstitial lung disease (CTD-ILD) is between an autoimmune interstitial lung damage. Early immune-mediated damage to exudative lesions based alveolitis, leading to fibroblast activation, extensive damage to the lung parenchyma lung structure is destroyed, eventually forming between irreversible diffuse interstitial pulmonary fibrosis or honeycomb lung. With the progress of the disease can lead to pulmonary hypertension followed by respiratory failure and death. Western medicine is currently no effective drugs, and more glucocorticoid binding cyclophosphamide (CTX) and other immunosuppressive and anti-fibrotic medication. In recent years, Chinese medicine treatment of CTD-ILD reported a gradual increase in the combination therapy are better able to improve the clinical symptoms of CTD-ILD patients, improve the quality of life of patients, delaying disease progression. Professor Dong Zhenhua rheumatological disease for many years engaged in traditional Chinese medicine, Integrative Medicine, painstaking research in clinical practice for the treatment of disease has accumulated rich experience[Objective]Based on the treatment of128cases of Professor Dong Zhenhua CTD-ILD patients organize, summarize its pathogenesis, syndrome differentiation, distribution and treatment of drug syndromesideas and characteristics. For the future to improve the clinical efficacy, advantages of Chinese medicine treatment CTD-ILD, as well as further research and clarify TCM innovative research CTD-ILD therapeutic mechanism of action to lay the foundation[Method]By collecting instructors treatment of traditional Chinese medicine in Beijing Union Medical College Hospital outpatient clinic CTD-ILD cases with128cases and system consolidation, according to mentor syndrome type, to observe and analyze the characteristics and distribution of syndromes associated with gender, chest HRCT findings, whether the primary disease as Sjogren’s syndrome (pSS) and other aspects of the relationship, combined with the usual teaching mentor coaching and related papers published in recent years, Professor Dong Zhenhua summary of CTD-ILD pathogenesis, differential treatment, as well as other aspects of Herbal Prescription characteristics.[Results]1CTD-ILD in order Yin of two injuries (32.8%), and Yin two merging phlegm obstructing lung injury (22.7%) of two most common syndromes the syndrome distribution ratio in descending order:Qiyin two hurt> Qiyin two injured+phlegm obstructing lung＞DLS＞liver and kidney insufficiency＞Yin Dryness＞Qiyin two injured blood stasis+＞=less phlegm obstruct the lung and kidney qi stagnation+＞+rheumatism and kidney deficiency resistance network2The incidence of the disease is far less than male female gender was no difference in the distribution of syndromes3With the more serious chest HRCT findings, Qi syndrome more highlights, the difference was statistically significant.4between whether the primary disease cause ILD for pSS and syndromes, the association between the severity of chest HRCT performance and not statistically significant[Conclusion]1pathogenesis Features:pathogenesis is the vacuity to the virtual-based. Yin of lung, spleen and kidney of the virtual blamed deficiency, standard real sputum, fever, stasis in the lung. Pathogenesis total to virtual, phlegm, blood stasis is the key.2Differential Treatment characteristics:①divided deficiency, evidence and reality mixed card three categories, which Qiyinliangxu as the key, and throughout the disease always.②evidence may appear alone, but also in the acute onset of the imaginary, in which case you should treat the symptoms.③false is mixed deficiency syndrome in type and folders scattered empirical evidence, shows, CTD-ILD syndromes behave more complicated.④should be guided differentiation of organs, organs function to adjust the angle from the treatment.⑤TCM syndromes can be transformed into each other because people should be dynamic dialectical when due3Syndromes:①CTD-ILD in order Yin of the two injuries, both Qi and Yin phlegm obstructing lung injury associated with two kinds of the most common syndromes, the syndrome distribution ratio in descending order: Yin of two injuries＞Gas two female phlegm obstructing lung injury+＞DLS＞liver and kidney insufficiency＞Yin Dryness＞Qiyin two injured blood stasis+＞=less phlegm obstruct the lung and kidney qi stagnation+＞insufficient kidney+rheumatism resistance network.②The incidence of the disease is far less than male female gender was no difference in the distribution of syndromes.③With more severe chest HRCT findings, Qi syndrome more highlights.④cause ILD whether the primary disease between pSS and syndromes, and chest HRCT correlation between the severity of the performance are not obvious.4Herbal Prescription Features:good application liter collapsible soup treating lung disease, Western mutual participation, identifying diseases drugs, unauthorized use of traditional Chinese medicine for western attenuated efficiency, efficacy is outstanding.