Naoxintong For Stroke Recovery And Sequelae Of ASDP And Endothelial Function In Patients With Syndrome Factors Influence

Background:Stroke is one of the three major causes of death in human diseases, the disability of acute phase is fast. It is difficult to improve the disability degree of recovery and sequelae period, It brings heavy burden to society and family, Soresearching the stroke has important practical significance.Stroke in western medicine belongs to the category of cerebral apoplexy. Stroke divided intoischemic stroke and hemorrhagic stroke. Ischemic stroke includeatherothrombotic brain infarction,lacunar infarction and cerebral embolism. Atherothrombotic brain infarctionaccounts for about70%of thetotalcerebral apoplexy.There is no western medicine can effectively improve the clinical symptoms of patients with stroke in recovery and sequelae period.The effect which Chinese herbal medicine based on dialectical treatment of TCM has for recovery and sequelae period is obvious. Stroke pathogenesis is complicated. The deficiency of blood stasis isone of the most common types of the stroke in recovery and sequelae period.So study theqi deficiency blood stasisyndromesand treatment of stroke in recoverysequelperiod isimportant.Vascular endothelial function isclosely related to cerebrovascular disease. Brachial artery ultrasound evaluation of endothelial function as a kind of simple method which has been reported, but the report of endothelial function relationship between qi deficiency and blood stasis syndrome elements of reporting is less. The Study of NaoXinTong treatment for cerebral infarction is more, but the evaluation methodof vascular ultrasound is less.The study is which observe the relation between the syndrome elements of stroke recovery and sequelae period qi deficiency blood stasis and endothelial function through brachial artery ultrasound and the situation of vascular endothelial function and deficiency of blood stasis after taking NaoXinTong capsules.The last isproviding to practical basis for mend matters of the clinical symptoms andvascular endothelial function of the patients with stroke recovery and sequelae period.Objective:Firstly,To explore the relevance between endothelial function andthe syndrome elements of the Qi deficiency and blood stasis.The syndrome elements has the phlegm the hot the Qi deficiency and blood stasis.Secondly,To explore the function which NaoXinTong improvethe endothelial function nerve function defect symptom clinical symptoms of traditional Chinese and brachial artery intima-media thickness in patients with stroke recovery and sequelae period qi deficiency blood stasis;Thirdly,To explore whether NaoXinTong can reduce the incidence rate of stroke patients with qi deficiency blood stasis or not.MethodsCollectencephalopathy department inpatient and outpatient stroke patients from Beijing university of Chinese medicine east hospital and dongzhimen hospital from March2011to January2014. The standard set:Stroke in recovery or sequelae period belong to qi deficiency blood stasis, cerebral infarction belong to atherosclerotic. Randomly divided into two groups, one group for the treatment group,the other group for the control group. The treatment group have16patients, the control group have14patients. Evaluation the score of TCM symptomatology NIHSSQideficiency syndromeblood stasisphlegm syndromehot syndrome and yin deficiency and yang excess on the same day. The score of TCM symptomatology is greater than or equal to6points.Test brachial artery endothelial function that is the difference value of brachial artery’s inner diameter before and after the reactive hyperemia and test the brachial artery intima-media thickness. Treatment group adopt NaoXinTong capsule oral plus traditional Chinese and western medicine symptomatic treatment,4grain NaoXinTong capsules each time,0.4g/grains, three times a day. The control group use traditional Chinese and western medicine treatment. Two groups were observed for3months. Reiteration brachial artery endothelial function and brachial artery intima-media thickness,.Evaluates the score of NIHSS, TCM symptomatology after three months.Followed up forpatients from two groupsand observe their recurrence rate of srroke within1year of surffing.from the diseases.ResultsThe frist,The relationship between the syndrome element score and FMD value:the correlation analysis of the syndrome element score of Qi deficiency, blood stasis, sputum with FMD comes out that the relationship between sputum and FMD is the strongest. From strong to weak, the relevancy with FMD is blood stasis, heat, qi deficiency, they are all of the negative correlation, in other words, the bigger the FMD is, the lower the endothelial function is. Among these relevancies, the relevancyof sputum, blood stasis and heat with FMD value are of statistical significance (P<0.05).The second,The comparison of NIHSS scores:First, the NIHSS scores of the treatment group are reduced compared with the scores before the treatment, they are of statistically difference (P<0.05), Second, the NIHSS scores of control group are reduced compared with the scores before the treatment, they are of statistically difference (P<0.05). Third, the NIHSS scores of the treatment group are all lower than the control group, the NIHSS scores of two groups are of no statistically difference after the treatment(P>0.05). The third, The comparison of TCM syndrome scores:the TCM syndrome scores of the patients with cerebral infarction in the two groups are both obviously reduced after the treatment, the differences are of statistical significance (P<0.05). The TCM syndrome scores of the patients with cerebral infarction in the treatment group and all lower than the control group, the difference isof nostatistical significance (P>0.05).The forth, The comparison of FMD value:the FMD value of the two groups before and after the treatment are both of no statistical significance (P>0.05). After the treatment, the FMD value of the treatment group is of no statistical significance compared with the control group(P>0.05).The fifth, The comparison of IMTvalue:the IMT value is of no statistical significance before and after the treatment in the two groups(P>0.05). After the treatment, the IMT value of the treatment group is of no statistical significance compared with the control group(P>0.05).The sixth, The comparison of recurrence rate:after one-year’s follow-up, the recurrence rate of cerebral infarction in the treatment group is lower than the control group, while the difference is of no statistical significance(P>0.05).ConclusionThe first, The relationshipfrom big to small in turn between vascular endothelial function and qi deficiency with blood stasis syndrome which is the phlegm blood stasis the heat qi deficiency.They are all negative correlation what means is more score of these Syndrome elements and less score of FMD,worse endothelial function.The second, To a certain extent,NaoXinTong can improve the nerve function defect condition of stroke with qi deficiency blood stasis syndrome in recovery and sequelae period.The third, NaoXinTongcan improve clinical symptoms of Chinese medicine which qi deficiency blood stasis syndrome of stroke in recovery and sequelae period has.The forth, Compared with other treatments, NaoXinTong has no obvious advantage in improveing vascular endothelial cell functionfor stroke patients in recovery and sequelae period with qi deficiency blood stasis improvement.The fifth, NaoXinTongin improving brachial artery IMT of stroke with qi deficiency blood stasis in recovery and sequelae periodboth have no obvious effect.The sixth, NaoXinTongcan reduce stroke recurrence rate of the stroke with qi deficiency and blood stasis syndrome.