| Objective: To investigate the distribution characteristics of TCM evidence of hypertension combined with increased resting heart rate and the correlation between each pathological evidence element and risk factors.Methods: 186 patients with hypertension complicated with increased resting heart rate were selected,and the distribution characteristics of TCM syndromes of hypertension complicated with increased resting heart rate were studied retrospectively and prospectively.The diagnosis of the evidence was made by referring to Zhu Wenfeng’s "Identification of evidence" to investigate the distribution characteristics of the TCM evidence of hypertension combined with increased resting heart rate,and the correlation between the pathological evidence and risk factors was analyzed by single-factor analysis and multi-factor logistic regression.Results:1.A total of 186 patients with hypertension and increased resting heart rate were included and there are 101 men and 85 women.The age ranged from 24 to 86,with an average age of 55.20±13.37.Complications: dyslipidemia(63.4%),coronary heart disease(48.4%),carotid atherosclerosis(32.3%),arteriosclerosis of lower limbs(30.1%),cerebral infarction(25.8%)and diabetes(24.7%).2.The distribution of syndrome elements in the disease site is mainly liver,heart and spleen,and the order is liver(75.8%)> heart(40.9%)> spleen(32.8%)> stomach(8.1%)>kidney(4.3%)> lung(3.8%).The combination of syndrome elements in two disease sites is mainly heart+liver(21%)and liver+spleen(14%),and in three disease sites,heart+liver+spleen(5.9%).(2)As for the distribution of pathogenic elements,solid elements:phlegm(65.1%)> dampness(39.8%)> hyperactivity(22%)> blood stasis(19.9%)> qi stagnation(7.5%)> heat(2.2%),deficiency elements: yin deficiency(44.1%)> qi deficiency(36%)> blood deficiency(5.4%)> yang deficiency(4.3%);The combination of syndrome elements of diseases is mainly bi-pathogenic phlegm+dampness(14.5%),phlegm+blood stasis(9.1%),yin deficiency+yang hyperactivity(8.6%),phlegm+dampness+qi deficiency(4.8%)and phlegm+dampness+yin deficiency+yang hyperactivity(4.3%).3.Correlation between disease syndrome elements and risk factors in patients with hypertension complicated with increased resting heart rate:(1)Phlegm: LV P(0.038)<0.05,BMI P(0.000)<0.05,are statistically significant;(2)Blood stasis: DBP P(0.015)< 0.05 and smoking P(0.009)<0.05 are statistically significant;(3)Yang hyperactivity: smoking P(0.000)<0.05,dyslipidemia P(0.000)<0.05,and hypertension course P(0.000)<0.05 are statistically significant;(4)Qi stagnation: gender P(0.000)<0.05 is statistically significant;(5)Humidity: BMI P(0.002)<0.05 is statistically significant;(6)Yin deficiency: BMI P(0.037)<0.05 is statistically significant;(7)Qi deficiency: SBP P(0.000)<0.05 is statistically significant.Conclusion:1.Patients with hypertension combined with increased resting heart rate are between24-86 years of age,with more men than women.Dyslipidemia and coronary artery disease were the most common comorbidities.2.Liver,heart and spleen are the most common syndrome elements of disease location,and heart+liver is the most common syndrome element combination of disease location.3.The pathological elements are mainly phlegm,dampness,yin deficiency and qi deficiency,and the combination of pathological elements is mainly phlegm + dampness.4.There is a correlation between pathogenic evidence and risk factors in patients with hypertension combined with increased resting heart rate.(1)phlegm is positively correlated with LV and BMI;(2)blood stasis is positively correlated with smoking,while blood stasis is negatively correlated with DBP;(3)Yang hyperactivity is negatively correlated with dyslipidemia and duration of hypertension;(4)Qi deficiency is negatively correlated with SBP;(5)Qi stagnation is negatively correlated with gender;(6)Dampness is positively correlated with BMI;(7)Yin deficiency is negatively correlated with BMI. |
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