| Objective:Observation of Sulfotanshinone Sodium Injection treatment of coronary heart disease angina patients of blood stasis syndrome of clinical curative effect and the change of CRP, blood lipid, blood sugar, liver and kidney function, such as physical and chemical indicators,discusse the curative effect and the security of Sulfotanshinone Sodium Injection when it is used with western medicine. in the treatment of coronary heart disease angina drug safety and effectiveness of the blood stasis.Methods:Between January2013and December2013in Chinese academy of sciences gate hospital cardiovascular internal medicine of traditional Chinese medicine hospital,80cases of coronary heart disease (CHD) patients. Using randomized controlled group patients were divided into two groups of equal number. Conventional western medicine treatment control group40people, give different isosorbide dinitrate10mg+5%glucose injection,100ml aspirin enteric-coated tablets, qd, and oral aspirin100mg, qd, metoprolol tartaric tablets12.5mg, qd, atorvastatin calcium tablets20mg calcium, qn, according to the corresponding merge disease related to suit the medicine, but not used drugs containing salvia miltiorrhizae or salvia miltiorrhizae preparations. Sulfotanshinone Sodium Injection treatment group40people, in the control group on the basis of conventional treatment combined with Sulfotanshinone Sodium Injection80mg+5%glucose injection250ml ivgtt, qd.Results:1. Sulfotanshinone Sodium Injection the angina treatment efficacy of sodium sulfonate injection:A show efficiency of the treatment group was65%, total effective rate was92.5%, the control efficiency of40%, the total effective rate was75%, comparison to the total effective rate, P=0.033<0.05there was a significant difference results.2. Sulfotanshinone Sodium Injection treatment group and control group in the changes of blood stasis syndrome, compared with pre-treatment, the treatment group significant efficiency of47.5%, the total effective rate was90%, the control efficiency of25%, the total effective rate was72.5%, comparison to the total effective rate, P<0.05there was A significant difference results.3. Sulfotanshinone Sodium Injection treatment group and control group of lipid levels in comparison:compared with pre-treatment, the treatment group and control group of total cholesterol, triglyceride, low density lipoprotein-cholesterol levels decreased obviously, which compared with statistical difference (P<0.01), HDL levels increase obviously, the two was statistically difference (P<0.01); And after treatment, the treatment group of total cholesterol, triglyceride, low density lipoprotein-cholesterol levels decreased more obviously than the control group, and a statistically significant differences (P<0.05), the treatment group of high density lipoprotein-cholesterol levels higher than the control group no significant, and no statistically differences (P=0.05).4. Sulfotanshinone Sodium Injection treatment group and control group before and after the change of c-reactive protein:compared with pre-treatment, the treatment group and control group of c-reactive protein were significantly decreased, with a significant difference (P<0.05); And as compared between the two groups after treatment, the treatment group than the control group obviously change, and(P<0.05), and a statistically significant differences.5. Cereal third transaminase in two groups of patients and make statistical comparison aspertate aminotransferase, respectively for the two groups pre-treatment, the two groups pre-treatment and posttreatment as well as t test, the two groups posttreatment of P values>0.05, no statistical significance.6. On two groups of patients with serum creatinine and blood urea nitrogen, statistical comparison of each of the two groups before treatment, the two groups before and after treatment as well as t test, the two groups after treatment of P values were greater than0.05, no statistical significance.Conclusion:1. Sulfotanshinone Sodium Injection can improve the angina of coronary heart disease in patients with unstable angina and blood stasis, indicates that it is effective treatment for coronary heart disease angina blood stasis drugs.2. Sulfotanshinone Sodium Injection can significantly reduce coronary heart disease angina patients with blood stasis serum CRP level, show it has anti-inflammatory effects 3. Sulfotanshinone Sodium Injection can significantly reduce coronary heart disease angina patients with blood stasis serum total cholesterol, triglyceride, low density lipoprotein-cholesterol, showing it can adjust blood lipid.4. Sulfotanshinone Sodium Injection in the treatment process did not cause obvious adverse reaction, do not affect kidney function, suggests that Sulfotanshinone Sodium Injection in the treatment of coronary heart disease angina is safe when blood-stasis happen. |
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