PINK1 Gene Polymorphism And Genetic Susceptibility To Yunnan Yuxi Leprosy Crowd

Leprosy is a chronic infectious and guanulomatous disease caused byMycobacterium leprae (M. leprae). M. leprae parasitize schwann cell and macrophage,affects human skin and the peripheral nerve systems. Research of leprosy found thatgenetic factors may confer susceptibility to it. Genetics association study become hotarea. A lot of regions and genes had been found correlate to leprosy susceptibility,such as10p13,6q25-26,6p21regions and TLR1, NOD2, VDR genes.2009, Zhang et,al. reported7genes associated with leprosy in human genome by genome-wideassociation study (GWAS).Until now, M. leprae can not be culture in vitro due to an exceptionally erodedgenome. The high level of inactivation of gene function in M. leprae. These charactersmean that the pathogenic bacteria relies on the host energy metabolism. Recently,results of our researches suggested that mtDNA copy number affects the lepromatousleprosy susceptibility. We hypothesized that mitochondria may affect hostsusceptibility to M. leprae because of the relation between mitochondria and innateimmunity leprosy.PTEN induced putative kinase1(PINK1) locate at mitochondrial outermembrane and play a key role in maintain mitochondrial homeostasis. PINK1is asusceptibility gene of parkinson disease (PD). We detected527leprosy cases and583controls from Yunnan province, but no significant results had been found (rs1043424,P=0.940; OR,0.990[95%CI,0.809-1.235]; rs10916840, P=0.402; OR,0.930[95%CI,0.741-1.167]; rs10916832, P=0.624; OR,0.915[95%CI,0.740-1.132];rs650616; P=0.623; OR,0.969[95%CI,0.788-1.190]).The negative results may caused by the less SNPs we detected or exclude therelation between PINK1gene and leprosy susceptibility.