Berberine Wendantang Treating Systematic Evaluation Of Insomnia

Objective:To evaluate the efficacy and safety of Huanglian Wendan Decoction treatment of insomnia.Methods:In accordance with the method of systematic review prescrib-ed by the Cochrane Collaboration, develop search strategies, and compr-ehensive search Randomized controlled trials (RCT) at home and abroad about Coptis Wendan decoction in the treatment of insomnia, includi-ng electronic searches of Tsinghua Tongfang CNKI database, the VIP, Biomedical Literature Database (CBM), Wanfang database, EMBASE CD-ROM databases, MEDLINE and Cochrane, hand searches of medical journals in Chinese, screening literature, based on the inclusion criteria and exclusion criteria, then assessing the literature included according to the’risk of bias assessment standards’from Cochrane Systematic Revi-ew’s manual recommended, and Meta-analysising of the data using RevMan5.2software.Results:There are11RCTs included1047patients. The qualities of these RCTs were poor. Meta-analysis of8studies shows pure traditional Chinese medicine the Huanglian Wendan Decoction’s treatment of insomnia can improve the efficacy compared with western medicine:RR=1.31,95%CI [1.23,1.41], R<0.00001. Meta-analysis of2studies shows the Huanglian Wendan Tang Combined with Western Medicine’s treatment of insomnia can improve the efficacy compared with western medicine:RR=1.34,95%CI [1.11,1.61], P=0.003.1study by using of chi-square test shows the Huanglian Wendan decoction can improve total efficiency in patients with insomnia compared with placebo.Conclusion:According to Systematic reviews, we get the prompt:for the treatment of insomnia, the method with traditional Chinese medicine Coptis WenDan Decoction or together with Western medicine, is effective and safe. But generally low methodological quality and potential publication bias affected the reliability of the conclusions. Therefore, there is a need for high-quality large sample, multi-center clinical randomized controlled trials, to provide conclusive clinical evidence for the treatment of insomnia with Coptis Wendan decoction.