| ObjectiveTo explore the target effectiveness of Ding Kun Dan (DKD) on dysmenorrhea (syndrome of cold congealing and blood stasis) by the infrared thermal imaging technology.MethodsVolunteers were collected from August,2012to April,2013, including women for health routine examination, female patients in the Second Affiliated Hospital of Chengdu University of TCM, and volunteers from Chengdu University of TCM. The constitutional questionnaires were filled in, established by the Syndrome Differentiation Standard of TCM. Volunteers with yang deficiency and neutral constitutions were scanned by Beijing Yuetian HIR-2000infrared camera. The thermal images about10to11pictures were achieved, and8regions calorific values were measured including forehead, lower abdomen, uterus, Sheque point, Du Channel, Ren Channel and either left or right foot. Those whose constitutions were cold congealing and blood stasis were scanned in the5th to12th day of menstrual cycle, Omin before taking warm water (DKD), and30min、70min、100min、130min、160min after taking warm water <3.5g DKD with equal volume of warm water) respectively. The warm water group was the control group, in which the thermal values of59locations all over the body were analyzed, including the head (forehead, face, the upper posterior head, the middle posterior head), chest-abdomen (chest, the upper abdomen, the middle abdomen, the lower abdomen, the uterus, left breast and right breast), back-waist (upper, middle, lower), limbs (bilateral anterior upper arms and the forearms, thumbs, index fingers, middle lingers, ring fingers and little fingers, palm centers, major thenars, minor thenars, dorsal hands, anterior and posterior thighs and calves, knees, popliteal fossas, anterior and posterior feet). Du channel, Ren channel, and Shenque point. Then, the target evaluation criteria were established as following: the calorific difference value between Omin and ones at all timings in both groups was first calculated. Secondly, the calorific values of two groups were compared and the tendency chart was drawn.①When the peak was not indicated, the overall increase was compared and the highest one was regarded as the target.②When the peak was indicated, the peaks were compared and the highest peak associated location was regarded as the target. If du meridian and ren meridian are included, after removal of du meridian, ren meridian and the one which still meets the above criteria was also the target). Consequently, the DKD targets were revealed. All patients with dysmenorrhea were scanned overall in premenstrual time. The dysmenorrhea symptom scale, TCM syndrome scale and constitutional scale were filled, which were established as the Guiding Principles of New Drug of TCM, the Gynecology of TCM and the Classification and Determination of TCM Constitution. All patients were asked to take DKD after menstruation,3.5g once, twice daily, one month as a course. Finally, they were scanned in premenstrual time, and all scales were filled one more time. Scores were calculated and the calorific values of forehead, lower abdomen, uterus, Shenque point, Du channel, Ren channel and feet were measured before and after medication.Results1.There were140cases in total, including72Yang deficiency and68neutral constitutions, in which36cases in spring (from March to May) including19Yang deficiency and17neutral constitutions, in which32cases in summer (from June to August) including16Yang deficiency and16neutral constitutions, in which37cases in autumn (from September to November) including18Yang deficiency and19neutral constitutions, in which35cases in winter (from December to February) including19Yang deficiency and16neutral constitutions.There were1120calorific valued measured, among which the calorific values of feet in Yang deficiency group at December-February were significantly lower than those in neutral group.(P<0.05), among which the calorific values of the forehead in neutral group at March-May were significantly higher than those at September-November, and December-February (P<0.05).In the lower abdomen, the calorific value of Yang deficiency group at June-August were significantly higher than those at September-November and December-February (P<0.05). The calorific values of the neutral group at June-August were significantly higher than those at March-May, September-November and December-February (P<0.05), while the calorific values at September-November were significantly higher than those at December-February (P<0.05). Ulerus area: in both groups, the caleriile values at June-August were significantly higher than those at December-February, March-May and September-November (P<0.05). Furthermore, in the neutral group, the calorific values at March-May, and September-November were significantly higher than those at December-February (P<0.05).Shcnque point: The calorific values in Yang deficiency group at June-August and December-February were significantly higher than those at September-November (P<0.05), while the calorific values in neutral group at June-August were significantly higher than those at March-May (P<0.05).Ren channel area: the calorific values in the neutral group at June-August were significantly higher than those at March-May, September-November, and December-February (P<0.05);Feet: in both groups, the calorific values at March-May, June-August and September-November were significantly higher than those at January-December (P<0.05); the calorific values at June-August were significantly higher than those at March-May (P<0.05). In Yang deficiency group, the calorific values at September-November were significantly higher than those at March-May (P<0.05).2.9volunteers with dysmenonhea in cold congealing and blood stasis syndrome were collected. Each was scanned12times and108person/time dynamic infrared thermal image scans were completed.59regions associated calorific values were observed and6372calorific values were obtained in total. The calorific values of right posterior forearm, right thumb, right index finger and right dorsal hand in DKD group, were lower than those in control group, while calorific values of all other regions were higher than those of control group at certain timing.On the head, the calorific values of posterior upper head increased dramatically to0.73℃. On the chest-abdomen, the calorific values of Ren channel increased dramatically to1.04C, followed by the uterus to0.69℃. On the waist-back, the calorific values of Du channel increased dramatically to0.6°C, followed by the upper back to0.36°C. On the upper limbs, the calorific values of anterior arm increased dramatically to1.12℃, followed by anterior forearm to1.10°C. On the lower limbs, the calorific values of posterior calf increased dramatically to1.12℃. On the hand, its tendency was irregular. However, they all indicated an increasing tendency and the calorific values of palm center increased dramatically to0.89℃.3.18times scans before and after medications were completed and144region associated calorific values were observed. After one month medication, patients’ scores of symptoms, TCM syndrome and Yang deficiency constitution were significantly decreased. The calorific values of forehead, lower abdomen, Shenque point, Du channel and Ren channel were increased, while the calorific value of the uterus and feet were decreased.Conclusion1.The calorific values of lower abdomen, uterus and feet in both Yang deficiency and neutral constitution decrease in winter and increase in summer. The calorific values of feet in Yang deficiency women decline significantly more than neutral woman in winter.2.DKD might increase calorific values of most body regions in dysmenorrhea patient with syndrome of cold congealing and blood stasis.It has the function of warming yang.3.The targets of DKD focus on the uterus, upper posterior head, upper back, anterior arm, anterior forearm, posterior calf, palm center, Du channel and Ren channel.4.Infrared thermal imaging technology might be a new effective method to evaluate compound formulas of TCM, and the further study might be essential. |
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