Collateral Diseases Treatment Of Diabetic Peripheral Neuropathy

Objective: This article will explore the pathogenesis of diabetic peripheral neuropathy(DPN) from the theory of “persistent illness entering collaterals”,which was comed up byTian-shi Ye.And provide the theory basis for treating this disease from the perspective of“eliminate coagulated and recuperate energy channels”.Methods: After studying related sections of 《A guide to clinical practice withmedical record》of Tian-shi Ye and modern collaterals theory.Widely consult related recordsabout mechanisms and therapy for DPN of domestic and overseas scholars in recentyears.Categorize DPN as collateral disease, contrast it witth modern medical research onmechanism of DPN microvascular diseases. At the same time according to physiologic andpathologic characteristics and therapeutic principle of collateral disease. Combine modernpharmacological studies of the activating blood and resolving stasis medicines with classicclinical case reports. Present a feasible program for treating DPN from the perspective ofcollaterals theory.And elaborates the importance and feasibility of treating DPN with theway of “eliminate coagulated and recuperate energy channels”. Establish social andeconomic benefits from Clinical treatment of DPN using collaterals theory.Conclusion: DPN belongs to the category of collateral disease in TCM. Cause to tinycollaterals，Qi and blood cycle slowly, easy to virtual and delay. Diabetes leads to spleen andstomach dysfunction，Qi and blood run out all over the body and collaterals. Phlegm turbidityand blood stasis delay in collaterals because of qi deficiency. At the same time, vesselsbecome empty because of blood deficiency,vessels lose smooth and fluency and becomedully. So phlegm turbidity and blood stasis delay in collaterals.There will be numbness andpain as early symptom of DPN because of body’s lacknesss of nutrition.But collaterals remainintact at this time,it is called the disorder of hemodynamic alterations of cerebralmicrocirculation and Unusually high of coagulation function in modern medicine. Onlyfunctional damage to vascular endothelial cells, but its structure have no significantpathological changes. DPN is a chronic episode and difficult to recover. There will becollaterals stasis and obstruction because of losing nourishment for a long time. The microvascular nourishing nervous possible stenosis or occlusion at this time. The medicinefor activating blood circulation and eliminating stasis can improve hemodynamics of theDM patients and animals, enhance antioxidant capacity,inhibit of cell apoptosis.,raise thelevel of NGF expression in nerve tissue,etc.to have neuroprotective effect.