Pharmic Research Of The Fufang Qingteng Tablet

Sciatica is a sort of familiar and frequently-occuring disease, which seriously hurtthe healthy of the humans, its characteristic is breaking out repeatedly, being of longduration and difficultly being cured. It often influence the work and study, even, seriouslyworking ability can be lost, which is too painful to bear. Sciatica stands first on the list ofall kinds of neuralgia in intestine, so, we should empolder new drugs for Sciatica, whichhas big market capability, good economic benefit and obvious society benefit.The Fufang Qingteng Tablet comes from the clinic empirical prescription of prof.Zhou zhong-ying. It’s composed of seven Chinese crude drugs: Caulis Sinomenii,RhizomaDrynariae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, etc, with theeffect of activating blood circulation to dissipate blood stasis, curing arthralgia spasm andrelieving pains. It has good effect for sciatica. The original form of prepared drugs isdecoction of herbal medicine, but because of bad taste of decoction of herbalmedicine,inaccurate dosage and necessity of casually preparation, It is already unfitted formodern clinical use of drugs, also, it is hard to control quality and to ensure the curativeeffect, so, we should change decoction of herbal medicine into troche, in order to controlthe quality preferably, to ensure the curative effect and to be convenient for the take andschlep of sufferers, also to be convenient for store and transport.According to the standard of the six type of Chinese new drugs, a systematicallyresearch on pharmic, the technologic, quality standard and preliminary stability of FufangQingteng Tablet is carried out as follows:1. With the guidance of the traditional Chinese medicine and the achievement ofmodern chemistry and pharmacological research, the source of this prescription and thesignificance of developing this issues is elalorated widely.2. According to systemic pharmacological experiment, it is approved that The FufangQingteng Tablet has the effct of promoting rehab of scathing sciatic.3. Based on the literature and the character of effective ingredient of originalprescription medicinal materials, we dispart the medication into two groups. The first groupis composed of six Chinese crude drugs: Radix Angelicae Dahuricae, Caulis Sinomenii,Cortex Cinnamomi, etc, they are distilled by ethanol, scientific orthogonal experiment isdesigned, the yield of Sinomenine and Cinnamaldehyd and extract is used as assessmenttargets in the first group, we select the best technologic of extracting, so that, we can ensure the content of effective ingredient and reduce the condensate of preparation, thereby,the dosage of orally take is reduced. The second group is composed of one Chinese crudedrug: Radix Et Rhizzoma Notoginseng, we comminute the original medicinal materials, itcan not only reduce the destroy of effective ingredient, but also can be used as adminicle ofmoulding.4. A lock of tests are used to select other optimum technologics of the preparation—theoptimum condition of concentration, desiccation, preparative technology, and suitableauxiliarant.5. Based on perfective study of technics, in ororder to insure the quality of thepreparation, TLC, HPLC, and other methods are used to assess the quality of the crudedrugs, raw product and preparation. The methods to determine contents of Sinomenine andthe TLC methods to determine quality of Rhizoma Wenyujin Concisum, Cortex Cinnamomi,Rhizoma Et Radix Notopterygii, Caulis Sinomenii and Rhizoma Drynariae have been setup and the experiment show that those methods are simple and accurate. Finally, the qualitystandard is established.6. The preliminary stability of Fufang Qingteng preparation is studied by observing theremained samples under the indoor temperature, and the results show that The FufangQingteng Tablet is stable in three months.