Study On Quality Standard And Preliminary Stability Of Liqixiaoying Tablet

Liqixiaoying tablet is totally of traditional Chinese medicine radix mainly composed of Citrus Veticulata Blanco and Bupleurum chinense DC,is an effective angent for treating Ying disease by reinforcing Qi,nourishing yin,,somthing liver,smothing pressuer.The author has made an experimental study on its quality standards and stability researchs.1. study of quality standardStudy on TLC qualitative:identify the nine kinds of crude drug in the preparation by TLC. Experimental results show that the product in reference substance chromatography corresponding control medicinal materials or position, all show the same color spots, and the negative control in the corresponding position is no interference. And after repeated experiments, the reproducibility is good.Study on determination:determined the content of Aurantiamarins in the preparation by HPLC;chromatographic column:Aichrom Bond -AQ C18 (250mm x 4.6 mm,5μm), Mobile phase:methanol-water (40:60); Velocity 1.0 mL·min-1; Column temperature 35℃; detected wavelength 284nm.The results of the content of Aurantiamarins isl not be less than 6.653 mg in each tablet2. study of organic solvent residual and HPLC fingerprintStudy on organic solvent residual:determination he content of organic solvent in the preparation by Headspace-GC;The results of Benzene is less than 0.0002%,and n-Hexane,Toluene,Xylene,Styrene and Divinyl benzene are not respectively detected in the preparation.Study on HPLC fingerprint:first,HPLC fingerprint of Liqixiaoying tablet intermediates are established by study on 10 batches of Liqixiaoying tablet intermediates, showing 13 common peaks and similarity>0.9,peak 4,7,10,and 12 as Sinapine thiocyanate,Aurantiamarins,Tubeimoside land Radix Stellaviae a. secondly,HPLC fingerprint of Liqixiaoying tablet preparations are established by study on 10 batches of Liqixiaoying tablet preparations,showing 13 common peaks and similarity>0.9.3. research on the stability of pharmaceuticalFor the sake of Preliminary stability of the mediaction,ensuring the satabilization of quality when the medication being leave in care.Overpass seeing about the fringe satabilization of the medication.The result of preliminary stability indicated that the result of characters,identifications, test.It showed that the quality is stabilized.