| Sjogren’s syndrome (SS) is a kind of Chronic systemic autoimmunedisease. It often infringes upon lacrimal, saliva gland and other exocrineglands. In addition, it has multisystemic damage on the other exocrineglands and organs. The pathogenesis is not clear so far. Although thereare many treatments, but most of them are only for treating thesymptom, and have no special effect thereby. The clinic curative effectand security all need a further confirmation. We summarized the regularityof therapy of SS, and pass with the hydroxychloroquine treatmentproject of control experiment, we have discussed and studied the curativeeffect and security of Chinese traditional medicine Sheng Jin grain.Theoretical research: The sjogren’s syndrome is attributed to thescope of ZaoZheng in TCM. There have many different minds aboutthe pathogenesis, but most people thought that YinXu is the basicpathogenic factor. The deficiency of Qi and Yin exists in the wholecourse of disease. The pathological nature is deficiency of origin andexcess of superficiality. At present, the study in Western medicine aboutthe pathogenesis and treatment of SS has made a little progress, butstill have many problems on the definitude of the curative effect index,the specificity of the treatment plan, as well as the medicine side-effectcontrol. In comparison, Chinese medicine has some advantage, but then, ithas no optimized project which can be repeated and popularized. In all,TCM is an important method to improve the existing project ofdiagnose and treat of SS, but itself still needs to be improved.Clinical research:Aim: Through the control experiment with hydroxychloroquine, make the objective evaluation about the curative effect and security of Chinesetraditional medicine Sheng Jin grain.Method: Forty six patients with primary sjogren’s syndrome andYinXuNeiZao were brought into with the principle of non-blindness,randomness, and controll. These patients were divided into two groups,each group had twenty three patients. They have differently been treatedby ShengJin grain and hydroxychloroquine. The period of treatment wereboth three months.Result: The clinical effective rate of TCM was 65.22%, and thewestern medicine was 43.48%, the result had no statistical significance(P＞0.05). After treatment, the self-estimate and life quality of thepatients with Chinese medicine were better, the result had statisticalsignificance (P＜0.05), especially in alleviating the thirst and the mouthcausalgia (P＜0.01). The states of ESR in the two groups were bothimproved, the differences had statistical significance (P＜0.05). Both theShengJin grain and hydroxychloroquine had favorable security, there hadno significant difference.Conclusion: Chinese medicine ShengJin grain can improve theself-conscious symptoms of the patients with pSS, especially in alleviatingthe thirst and the mouth causalgia. In controlling the inflammation,ShengJin grain also have assured curative effect. ShengJin grain havefavorable security in treating the SS. |
