Comparison Of Two Methods In The Treatment Of Secondary Hemophagocytic Syndrome In Children

Objective: hemophagocytic syndrome, HLH is a common pediatric blooddisease,Which process is very fast, clinical manifestations are diverse, and because ofthe particularity of pediatric patients, Its early diagnosis is too difficult to make the sickchildren receive timely treatment, its mortality rate is very high, the current alternativetherapies for the treatment of HLH is very few. the plan of commonly used is HLH–04scheme early and standard chemotherapy regimens. This study compares the two kindsof the curative effect of chemotherapy regimens on children virus correlation of HLH,and through the retrospective analysis of clinical data, further explore the factorsinfluencing the diagnosis and outcome about children virus correlation of HLH, to early diagnosis and treatment, improve patient surial.Methods: Select the clinical data of40patients with HLH children viruscorrelation,which is admitted in the first affiliated hospital of zhengzhou universityfrom January2009to January2011.two different chemotherapy regimens were used toretrospectively analyzed the impact on the survival and recurrence rate.Applicat IBM19statistical software to perform Statistics analysis,The result were applied chi-square toperform statistical analysis.P <0.05is statistically significant.Risk factors related tochoose single factor analysis, to analyze multiple factors logistic method, P <0.05isstatistically significant. Results:(1) by comparing two kinds of chemotherapy regimens,two treatments have obvious difference statistically in cytomegalovirus infection group,.and curative effect in other group has no statistical difference.(2) Resaut with singlefactor analysis show that visible onset age, level of platelet, aminotransferase levelsassociated with outcome. Logistic multi-factor analysis is used to above factors, theresults show platlet and aminotransferase levels is independent risk factor.Conclusions:1. The children for the NO CMV infection patients with HLH, there are nodifference curative effect between the two kinds of chemotherapy.it suggest we may usethe HLH-04erly chemotherapy regimens.2. The children patients with cytomegalovirus correlation HLH, HLH-04standardchemotherapy is better than that of early chemotherapy regimens.3. Age, transaminase, platelet levels is the related risk factors. The lifetime of Patientswith different age groups is different, the smaller age, the lower survival rate; Thehigher of the transaminase level, the lower surial.