Age-related Changes In Ocular Higher-order WavefrontAberrations

Objectives:This study examines the characters of human ocular higher-order wavefront aberrations (HOAs) and correlation analysis on age-related change, with a purpose of providing theoretical and clinical supports to LASIK operation on different-aged higher-order wavefront aberrations and design of customized intraocular lens. This study also provides evidence on the identify the normal range of ocular higher-order wavefront aberrations with a variable of age.Methods:The data used in this study are collected by Wave Scan objective wavefront aberration measurement (VISX Co,USA.) and involves180wavefront aberrations observed values (half male and half female). These observations range from18to68years, and5age groups (36observations each group) are determined according to10-years age gap. The methodology in this study is correlation analysis, to examine the correlation between age and four different values (HOAs, spherical, coma, trefoil aberration) individually.Results:1. The mean Root-mean-square(RMS) of HOAs(0.371±0.153)μm increased with aging(r=0.450, p=0.000<0.05)2. The mean RMS of total spherical (0.173±0.129)μm, also had a positive correlation with age(r=0.391, p=0.000<0.05) 3. Positive correlations were found out between total coma (0.200±0.121)μm and age.(r=0.244, p=0.001<0.05)4. Total trefoil aberration (0.188±0.111)μm were increased with age.(r=0.255, p=0.002<0.05)5. There were no differences in gender.Conclusions:The HOAs, spherical, coma and trefoil aberration of ocular indices one positive movement with the age increased, whereas insignificance in gender.