Analysis Of The Factors Affecting The Prognosis Of Patients With Esophageal Squamous Cell Carcinoma

Objective:The survival of esophageal squamous cell carcinoma patients is influenced by multiple factors.Esophageal tumor length is an independent prognostic factor of long-term survival for with esophageal carcinoma patients.This study of univariate and multivaite analysis found the prognostic factors of survival, and find the esophageal lesion length best segmentation that effect the prognosis of patients. To investigate whether is relevance of barium meal and endoscope measuring esophageal lesion length.Methods:235patients with esophageal squamous cell carcinoma who had undergone resection between January2005and December2006in Shanxi Provincial Tumor Hospital were review. All patients were checked complete preoperative, including general physical examination, blood tests (blood routine, liver and kidney function, electrolyte and glucose), endoscopy, esophageal barium meal contrast, neck and chest and abdomen CT scan, neck and abdominal ultrasound.Through the strictly entry criteria,there were172patients into the group, all the data collected to establish a database, and statistical analysis.Results:1) The esophageal lesion length best segmentation is5cm using the ROC curves.2) Using sum test,we could obtain endoscopy and barium meal radiography were relevant(P<0.001).3)According to the esophageal lesion length.patients were divided into>5cm group and≤5cm group. We study the lesion length with age, sex, smoking history, drinking history, gastroscopy in length, tumor differentiation. T stage, N stage correlation, showed esophageal lesion length of more than5cm of esophageal squamous carcinoma patients than in patients with less than5cm T staging (P<0.001) and N stage (P=0.012) to the late. G stage to high (P=0.029).4) Patients were divided into postoperative metastasis group and non metastasis group, postoperative lymph node metastasis group and the group without lymph node metastasis, salvage therapy group and non salvage treatment group. Log Rank test results show that the occurrence of distant metastasis and salvage therapy on survival rate of patients with no effect; postoperative lymph node metastasis of>3. The survival rate of the patients lower than3and no patients with lymph node metastasis, lymph node metastasis≤3survival patients without lymphatic metastasis rate of less than.5) Univariate analysis was performed on all patients age, sex, smoking history, drinking history, barium meal in length, gastroscopy in length, tumor differentiation. T stage. N stage, multiple factors, results show that the staging and preoperative barium meal in the food canal lesion length for prognostic factors influencing survival of patients with esophageal squamous cell carcinoma patients postoperative T staging. N. has a significant impact on survival difference between the three, the P values were0.006,0.002and<0.001.6) Multivariate analysis showed preoperative T staging, N staging and postoperative esophageal barium meal in lesion length were the independent prognostic factors for survival of patients with esophageal squamous cell carcinoma, three were increased level, the risk of death increases.7) Give a Kaplan-Meier test on whether to quit smoking and wine, results showed two survival curves of different smoking and drinking were not statistically significant (P>0.05).8) Of patients in this study overall survival was1,2,3,4,5years were68%,54%,49%,44%,40%, the median survival period of45.6months.Conclusion:According to the ROC curves of esophageal lesion length barium meal in the best segmentation prognosis for5cm. Esophageal lesion length by endoscope and barium meal measurement have correlation. Staging and preoperative esophageal barium meal in lesion length were the independent prognostic factors for survival in patients with squamous cell carcinoma of the esophagus after the T stage, N, and5cm in patients with esophageal squamous cell carcinoma was≤5cm tumors invading obviously, prone to lymph node metastasis, tumor differentiation degree is high, poor survival, and lymph node metastasis is greater than the number of3is less than3and the prognosis of the patients without lymph node metastasis is poor. Whether there is distant metastasis, whether to quit smoking and wine on survival of patients with no obvious effect.