Analysis Of The Related Risk Factors For Liver Cirrhosis Ascites With Acute Renal Dysfunction

Objectives:The aim of this study is to understanding the risk factors of decompensatedliver cirrhosis complicated by acute renal dysfunction and providing reference forprevention and treatment for the complicationMethods: Collecting254clinical data of cirrhotic ascites patients, take the standardof serum creatinine higher than the upper limit of normal reference values，or overbaseline serum creatinine rises more than2times in two weeks (greater than226μmol/L) as the observation group, the normal range of serum creatinine in patients as acontrol group, clinical data base selected cases and related laboratory parameters wereretrospective analysed. Basic clinical information includes: gender, age, cause ofcirrhosis, liver cirrhosis course, and ending; related complications include: hepaticencephalopathy, upper gastrointestinal bleeding, spontaneous bacterial peritonitis (SBP)and other infections; laboratory indicators include: albumin, total bilirubin, serumsodium levels, prothrombin activity，white blood cell count, platelet count, and serumcreatinine. On selected indicators: gender, age, duration of cirrhosis, hepaticencephalopathy, upper gastrointestinal bleeding, spontaneous bacterial peritonitis, other infections, albumin, total bilirubin, serum sodium levels, prothrombin activity(PTA),white blood cell count, platelet count univariate analysis, in which the normaldistribution of the composite measurement data, including age, duration of cirrhosis,albumin, prothrombin activity using T test, does not meet the normal distribution usingZ test include: total bilirubin, serum sodium levels, white blood cell count and plateletcount; count data, including: gender, hepatic encephalopathy, upper gastrointestinalbleeding, spontaneous bacterial peritonitis, other infections using Chi-Square test. Afterusing univariate analysis, univariate analysis was statistically significant (p <0.05) usingLogistic regression analysis, analysis of risk factors for loss of independence in patientswith decompensated liver cirrhosis acute kidney injury.Results: Univariate analysis showed that gender, age, duration of cirrhosis of the liver,albumin, upper gastrointestinal bleeding, control group and the observation group wasnot statistically significant (p>0.05).The incidence of hepatic encephalopathy observedgroup accounted was50.4%，the control group (10.1%)，comparison between the twogroups was statistically significant (p <0.01);the incidence of spontaneous bacterialperitonitis(SBP) observed group was70.4%,control group (41.2%), comparisonbetween the two groups was statistically significant (p <0.01);the incidence of infection in other parts observed group was32.6%,the control group (19.3%), comparisonbetween the two groups was statistically significant (p <0.05);the median sodium levelsin the observation group was128，control group was136.8，comparison between thetwo groups was statistically significant (p <0.01)；the median serum total bilirubinlevels in the observation group was319.8,control group was51.6，comparison betweenthe two groups was statistically significant (p <0.01);the median leukocyte count(WBC)in the observation group was9.3, control group was3.9，comparison between the twogroups was statistically significant (p <0.01); Plasma prothrombin activity (PTA) in theobservation group34.2±17.3, control group52.1±16.1, the two groups werestatistically significant (p <0.01). Logistic regression analysis showed that hepaticencephalopathy, hyponatremia, total bilirubin, prothrombin activity, white blood cellcount may be an independent risk factor for the loss of decompensated liver cirrhosispatients with acute kidney injury (p <0.05)Conclusions Cirrhotic ascites with hepatic encephalopathy, infection, hyponatremia,hyperbilirubinemia and low plasma prothrombin activity are the risk populations ofcirrhotic complicated with acute renal dysfunction.