Correlation Between High Risk Factors, Magnetic Resonance Imaging And Gross Motor Function Of Children With Cerebral Palsy

Objective To investigate the relationship between gross motor function classificationsystem(GMFCS)and risk factors or magnetic resonance imaging(MRI) in children withcerebral palsy.Method One hundred and fifty-seven cerebral palsy children who were hospitalized inour center, were recruited from Jan.2012to Jan.2013. The basic information,perinatalrisk factors and MRI findings were reviewed and analyzed. GMFCS was used to definebe classification for gross motor function. The relationship between GMFCS and riskfactors or MRI was analyzed by step wise regression or chi square test.Results Among the151cases of cerebral palsy(26with spastic quadriplegia,63withdiplegia,38with hemiplegia,16with dyskinetic,3with ataxia,5with mixed type), Thedistribution of GMFCS levels were: I-40(26.49%), II-43(28.48%),III-302(21.19%),IV-27(17.88%), V-9(5.96%). There is a significant difference in GMFCS distribution indifferent clinical types of cerebral palsy(P<0.05). Among high risk factors, There is asignificant difference in GMFCS distribution in preterm, low birthweight and jaundice(P<0.05), and could be more likely to be GMFCS III-V when the factors were mixed.MRI abnormalities were identified in130of the151cases(86.09%),periventricular-leukomalacia,brain maldevelopment,basal ganglia orthalamus lesions,brain malacia or atrophy have significantly correlate with GMFCS levels(P<0.05). Subjects with normal MRI scans were most likely to have mild motorimpairment, with over four-fifth classified as GMFCS I–II.Conclusion The cerebral palsy children with different risk fctors have different degreeof gross motor function disability,and so with different MRI presentation. Analysis ofthe perinatal high risk factors and MRI characteristics playing an important role inpredicting clinical manifestation and motor function assessing.