A Study On The Correlation Between Suicidal Ideation And Drug Therapy And Relative Factors In Hospitalized Patients With Depressive Disorder

ObjectiveSuicide ideation is a major predictor of suicidal behavior. This study was to make a prospective observance of the patients with suicidal ideation and risk in the latest week, exploring the relationship between the changes of suicidal ideation and risk with drug therapy and related factors in the hospitalized patients with depressive disorder, in order to provide theoretical basis for clinical prevention of suicide.MethodsFrom November2010to November2013, We collect223patients in the hospitalized with depressive disorder came from Shandong Mental health Center.Firstly all patients were diagnosed by two or more deputy chief or chief physician used the criteria of ICD-10and CCMD-3,patients those Conform to the diagnostic criteria evaluated by the Suicide Attitude Questionnaire(QSA), Chinese version of Barratt impulsiveness scale (BIS-CV), Chinese version of Buss&Perry Aggression Questionnaire (AQ-CV), Beck scale for suicide ideation-Chinese version (BSI-CV), Beck hopelessness scale (BHS),Insight and Treatment Attitude Questionnaire(ITAQ), Hamilton Depression Scale (HAMD),Hamilton Anxiety Scale (HAMA),Clinical Global Impression(CGI)and basic personal and disease information questionnaire between1-5days. The treatment in the natural state, two weeks and four weeks after the first evaluation, we evaluated by the Beck scale for suicide ideation-Chinese version (BSI-CV), Beck hopelessness scale (BHS), Insight and Treatment Attitude Questionnaire (ITAQ), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Clinical Global Impression (CGI) again. All statistical analyses were performed using SPSS18.0software, Independent-Samples T Test, One-Way ANOVA analysis and Multiple Stepwise Regression were applied in this study.Results1. The results show that with the drug therapy the suicide ideation and risk in the latest week、hopelessness、depression、anxiety were reduced, insightwere recovery and the clinical effect is significant.2. The correlation analysis showed that:the suicide ideation of BSI-CV in the latest week had highly positive correlation with Beck hopelessness scale and Hamilton Depression in the first two evaluation (r>0.60), the moderate correlations between the third time of evaluation (r>0.40). The factor of suicide riskhad positive correlation with Beck hopelessness scale between three time of evaluation.3. The correlation analysis of showed that：in the first two evaluation of the latest week suicide ideation and risk had significant correlation with the Aggressive factor of AQ-CV; the suicide ideation had significant correlation with BIS-CV between the three evaluation.4. Based on the characteristics of patients with medication, including single antidepressant, two or more antidepressant, single antidepressant combine antipsychotic, two or more antidepressant combine antipsychotic, antidepressant combinemood stabilizer, antidepressant combine antipsychotic and mood stabilizer.There was no significant difference between the six groups of drugs,but have significant differences between three evaluation. In the same time the number of the patients with suicide risk have gradually reduced.5. According to the history of suicide attempts:there are significant differences between patients with depressive disorder with history of suicide and the ones without history of suicide in the the latest week scores of suicide ideation of BSI-CV (p<0.01). There was no significant difference between the latest week scores of suicide risk.6. The various general information, there are significant differences between patients with different sex and age (p<0.05)7. The various diseases information, there are significant differences between patients with different family history of psychotic、suicidal behavior with the ones without that positive family history (p<0.05)8. Family history of mental and suicide in the first two evaluation have significant influence on the score of suicidal ideation and risk (p<0.05).Conclusions1. The patients with depressive disorder whose the latest week of suicidal ideation, hopelessness, depression, anxiety degree gradually reduce, insight gradually recovery, has better clinical efficacy during the stay in hospital.2. During the drug treatment, the latest week suicide ideation and risk were closely related with Beck hopelessness scale.3. Along with the first two evaluation, Chinese version of Barratt impulsiveness scale and the aggressive factor of Chinese version of Buss&Perry Aggression Questionnaire have a significant impact on Beck scale for suicide ideation-Chinese version (BSI-CV).4. The patients with depressive disorder during the drug treatment, the scores of latest week suicide ideation and risk gradually decline,the numbers of the patients with suicide risk also reduced.5. The score of the patients with history of suicide is significant higher than those without history of the latest week suicide in the suicide ideation in BSI-CV.6. The score of the latest week suicide ideation in BSI-CV of female patient significantly more than in the male ones; The score of latest week suicide risk in the patients of17-18yeas highest.7. The score of the patients with family history of psychotic and suicidal behavior is significant higher than those without positive family history.8. Family history of psychotic and suicide behavior have more significant influence on latest week BSI-CV.