| Purpose:Our objective was to evaluate the diagnostic value of squamous cell carcinoma antigen (SCC-Ag) serum tumor markers for the detection of cervical cancer and its prognostic value of the patients overall survival.Methods:The study included a total of198patients with a histologic diagnosis of cervical cancer and attending at First Affiliated Hospital of Guangxi Medical University over the period October2010through May2013. We determining the serum SCC-Ag level before treatment, and conducted a retrospective review of the patients’records. The Kaplan-Meier method was used for survival analysis. The Mantel-Cox method was used to compare overall survival.Results:The pretreatment SCC-Ag appeared rather specific for cervical cancer compared with other benign lesions of the uterine cervix, also correlating with pathology type of the tumor (Squamous cell carcinoma), clinical staging, tumor size and lymph node metastasis, but not tumor size, FIGO staging or patient age. Log Rank (Mantel-Cox) test shows pretreatment SCC-Ag was not a significant predictor for the3years overall survival (p=0.460).Conclusion:The pretreatment SCC-Ag appeared rather specific for cervical cancer compared with other benign lesions of the uterine cervix. SCC-Ag is a more sensitive serum tumor marker than CA125, CA199, CEA and AFP for squamous cell cervical cancer in most series. Pretreatment SCC-Ag levels in patients with cervical carcinoma were correlated with clinical tumor classification and clinical lymph node status, but not usable as a predictive or prognostic factor of overall survival of the patients. |
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