Correlation Between Osahs And Renal Injury: A Meta Analysis

Objective:obstructive sleep apnea syndrome can cause multiple system organ complications, in recent years, renal damage in the one with obstructive sleep apnea syndrome caused more and more attention. Serum cystatin C, urinary N-acetyl-β-D amino glucoside, urinary gamma glutamyl transferase, urea nitrogen, creatinine, often used as a marker to assess renal injury, this research through the evaluation of obstructive sleep apnea syndrome is associated with the above factors to reflect renal damage. Methods:Such databases as PubMed, EMbase, Web of science, Cochrane library, CNKI, CBM, VIP, wan fang Data electronic databases were searched to collect literatures including case control study and cohort study about the correlation between OSAHS and renal injury up to December2013. Two reviewers independently performed data extraction, quality evaluation and cross check, and Meta analysis was performed with RevMan5.2software.Results:A total of6case control studies was involved, including659subjects. Meta analysis showed that:the levels of serum cystatin C, NAG in light, medium, severe OSAHS patients were higher than those in the control group, the difference was statistically significant; the levels of serum Scr, GGT in medium, severe OSAHS patients were higher than those in the control group, the difference was statistically significant; the levels of serum BUN in severe OSAHS patients were higher than those in the control group, the difference was statistically significant.Conclusion:Current evidence suggests, obstructive sleep apnea syndrome patients had renal damage. The serum cystatin C, urinary N-acetyl P-D amino glucoside, urinary gamma glutamyl transferase, urea nitrogen and creatinine levels increased compared with the normal control group, and to suspend the relevant syndrome severity and obstruction sleep apnea. The research results still need more high quality studies to confirme.