Features Of Brain MRI In Pure Hereditary Spastic Paraplegia Of SPG6Types

Objective To discuss features of the brain MRI in hereditary spastic paraplegia of SPG6types and to raise knowledge of this disease.Materials and Methods Twele HSP patients were confirmed as SPG6by genetic linkage analysis. Frist, to measured the width of the corpus callosum genu,body,splenium and the area of cortex,whole corpus callosum by MRI in sagittal alignment. Second,to calculate the sum of the genu of corpus callosum, the sum of the body of corpus callosum, the sum of the splenium of corpus callosum,and the ratio of whole corpus callosum and the area of cortex.Third,to work out their average.As control subjects,400age-and-gender matched normal men were measured with the same method. Finaly, the average of patient group and control group were comparedResults Two patients brain MRI is normol. Thinning of corpus callosum and cerebral atrophy with different level on different parts was found in10cases. Among them, abnormal high signal was found in the central white matterin6cases, and one old patient showed abnormal signal in the right parietal region.And statistical differences between patient group and control group were found in the corpus callosum research, and the differences of the width of the corpus callosum genu,body,splenium were statistically significant (P<0.05).Conclusion There were typical MRI features in HSP of SPG6types, including thin corpus callosum,brainatrophy,symmetric abnormal signal in the central white matter.And the typical MRI features of pure HSP can be same to the complicated.