A Comparative Study Of HER2Detection In Gastroscopic And Surgical Specimens Of Gastric Carcinoma

Objective To analyze the difference of the positive rate of HER2expression between gastroscopic and surgical specimens of gastric carcinoma and investigate the feasibility of HER2detection in gastroscopic specimens to substitute surgical specimens.Methods Using immunohistochemical technique to detect HER2expression in gastroscopic and surgical specimens of200cases with gastric carcinoma.Results In the test of200cases of gastric cancer tissues,171cases in the gastrosopic specimens showed HER2protein expression (0/1+),6cases showed (2+), and23cases (3+); in the surgical specimens161cases expressed (0/1+),18cases (2+), and21cases (3+). The positive expression rate of HER2protein is10.5%; HER2protein in gastric cancer patients is consistent with the surgical specimens of gastroscope biopsy specimens at a rate of89%; Biopsy specimens from the expected negative HER2expression rate was96.6%; The Expected negative rate was80.95%; The overall coincidence rate was95%.200cases of gastric biopsy tissue samples can be divided into6groups of clinical pathology parameters for statistical analysis, Including gastric cancer tissue type (p=0.000) and cancerous tissue blocks (p=0.016) statistically significant difference in the two groups, Gender and gastric cancer patients (p=1), age (p=0.672), carcinoma tissue (p=0.345) and tissue based blocks (p=0.863) there was no statistically significant difference in four groups.Conclusion The positive rates of HER2expression in gastroscopic and surgical specimens of gastric carcinoma are basically the same. For the patients with inoperable advanced gastric carcinoma, gastroscopic specimens may substitute for surgical specimens for HER2examination. Thus, it may also provide reliable theoretical basis for targeted therapy.