Analysis Of Serum Magnesium And Lipid Level In Healthy Individuals&Effects Of Magnesium Supplementation On The Metabolism Of Lipid In Middle-aged People And The Eldly

Objectives:To investigate the correlation between serum magnesium and lipid levels in physical examination individuals, and to evaluate effects of magnesium supplementation on metabolism of lipid of the middle-aged people and the eldly.Methods:16260blood samples (8602males and7658females, from18to99years old and the average age were55.64) were collected in2009to analysis the serum magnesium, triglyceride(TG), total cholesterol(TC), low-density lipoprotein (LDL-C), and High-density lipoprotein (HDL-C). Pearson correlation linear regression was used for statistic analysis.150people aged from55to70were randomized into three groups: group C as a control, group E taking VE250mg/d, and group M taking magnesium220mg/d. Venous blood were taken from each subject before and after the3-month trial for measurements of total cholesterol (TC), high density lipoprotein (HDL), triglyceride(TG), apoprotein A (Apo A), and apoprotein B (Apo B).Results:1. The average serum magnesium concentration was1.76±1.20mmol/L, and there were no significant differences between males and females (P>0.05). With the age increasing, the serum magnesium rose in both genders. In male, below40years was the lowest, while≥71years group was the highest (all P<0.05), while in female, the two groups below55years were lower than the others, and group over71years was the highest (all P<0.05). TG level of those over56were significantly lower than those below55in male(all P<0.05). Otherwise, TG level gradually increased with age in female(P <0.05). TC of those over56was significantly higher than people below55in female (all P<0.05); while the TC in group over71was significantly less than other groups (all P <0.05). The average HDL-C level was1.33±0.31mmol/L in male, and there was no significant difference among all age groups (P>0.05); while the average level was1.52±0.36mmol/L in female, but group over71decreased significantly in female (all P <0.05). LDL-C level was2.90±0.97mmol/L in male, and the average level of group over70was2.78mmol/L, which was significantly lower than groups under71. LDL-C levels were significantly lower in group over56than under55(P<0.05). Serum magnesium has positive correlation with levels of TG(r=0.033), TC(r=0.038), and LDL(r=0.044)(all P<0.05), except HDL (r=0.000, P>0.05).2. After3months supplementation, TC levels of control groups E, and M decreased2.77mmol/L, and2.47mmol/L, respectively (P<0.01). HDL increased0.24mmol/L (P<0.01) and0.22mmol/L (P<0.01) respectively in groups E and M. TG increased2.28mmol/L in group C (P<0.01), but decreased2.83mmol/L and1.31mmol/L in groups E andM (P< 0.01). There were no significant differences in blood levels of Apo A and Apo B.Conclusions:Serum magnesium increased with age; serum magnesium has positive correlation with TG, TC and LDL-C. There were differences in serum lipid between different ages and genders. HDL-C levels were significantly higher in female than male, of which the mechanisms need to be studied further. Magnesium supplementation may improve the metabolism of glucose and lipid of the middle-aged and older people. Further research should be conducted to find the right dosage and duration of the supplementation.