The Value Of Serum Magnesium And Bilirubin In Early Diagnosis Of Diabetic Retinopathy

Type2diabetes mellitus (Type-2Diabetes mellitus) is a chronicmetabolic disease with high blood sugar a feature, mainly caused by therelative lack of insulin resistance and insulin. Various diabeticcomplications will be induced by poor glycemic control in diabeticpatients, and the complications of diabetes are the leading cause ofdiabetic death and blind. The diabetic retinopathy (DR) is the mostcommon ocular micro vascular complications of diabetes patients inChina, which also the main risk factor leading to blindness. DR willeventually lead to patients with irreversible blindness, which was due topoor early detection and treatment of diabetic retinopathy. It is veryimportant to the patients with diabetes mellitus that notice early diabeticretinopathy eyes often have no obvious clinical symptoms. Earlydetection and treatment play a key role in delaying the progress ofdiabetic retinopathy. Fundus fluorescein angiography and ocular fundusphotography are currently most common pre-diagnosis technologies, inwhich subject patients need additional test and take angiography agent. Itis very important to develop a convenient, fast and reliable earlydiagnosis of diabetic retinopathy.Objective：Bilirubin was associated with oxidant stress in diabetic retinopathy.This study was carried out to study the relationship between diabeticretinopathy and serum magnesium and bilirubin level. Methods：The data of152patients with T2DM in China-Japan Union Hospitalof Jilin University from Sep2012to May2014were retrospectivelyanalyzed, which has been divided into three groups (NDR, NPDR andPDR) according to the results of fundus photography. The basic data,serum magnesium and bilirubin level had been analyzed and compared.Results：The basic data showed that the Age, BMI, SBP, HDL-C, and ALThave no difference between PDR, NPDR and NDR groups. In contrast,the Duration, TG and LDL-C evaluated in PDR, NPDR compared withNDR (P<0.01).Total bilirubin were significantly different between PDR, NPDR andNDR groups (P<0.01), Moreover, patients with PDR had much lowertotal bilirubin than those with NPDR (P<0.05).The serum magnesium also were significantly different betweenPNR, NPDR and NDR groups (P<0.01), Moreover, patients with PDRhad much lower total bilirubin than those with NPDR (P<0.05).Conclusion：Lower serum magnesium and total bilirubin level was associatedwith the duration of diabetic retinopathy. The level of serum magnesiumand total bilirubin in NPDR and PDR groups were significantly lowerthan that in the NDR group.The significance:Researches on the relationship between serum level of magnesiumand total bilirubin with diabetic retinopathy were analyzed, whichdemonstrated that the bilirubin and magnesium ion in the diabeticretinopathy can slow down the development of diabetic retinopathy, which may due to their anti-oxidative stress role. Our programs provide atheoretical basis and experimental support for early diagnosis of diabeticretinopathy.