To Investigate The Influence Of Heavy-ion Radiotherapy On The Immune Function Of Patients With Maglignant Tumor

Objective To investigate the influence of heavy-ion radiotherapy on the immune function of patients with maglignant tumor.By detecting the changes of immuneglobulin,T-cells subgroups and NK cells.Methods In this study,from November2009to June2013,twenty-six patients with malignant tumor which had been pathologically were subjected to heavy ion rays local regional therapy. The radiotherapy total dose was36GyE-60GyE,according to the median of the radiotherapy dose55Gy,we divided26patients into>55GyE group and^55Gy group. According to the therapeutic part divided the patients into the group of chest, abdomen and pelvic group.The immunoglobulin (IgG, IgA, IgM) were detected by auto biochemical analysis instrument. T-cells subgroups and NK cells were detected by flow cytometry.Results:1.The IgG,IgM and IgA of patients after heavy-ion radiotherapy was not significantly different compared with before the therapy(P>0.05).2.The CD4+T,CD8+T,CD4/CD8and NK of patients after heavy-ion radiotherapy was not significantly different compared with before the therapy(P>0.05).3.The radiotherapy total dose was36GyE-60GyE,according to the median of the radiotherapy dose55Gy,we divided26patients into>55GyE group and≤55Gy group.The index of immune function after heavy-ion radiotherapy was not significantly different compared with before the therapy(P>0.05).4.According to treated areas,we divided26patients into chest group,belly group and pelvic group.The index of immune function after heavy-ion radiotherapy was not significantly different compared with before the therapy(P>0.05).Conclusions:The index of immune function after heavy-ion radiotherapy was not significantly different compared with before the therapy。 The index of immune function after heavy-ion radiotherapy was not related with the total dose and the treated area.