Determination And Clinical Value Of Soluble E-selectin And Tissue Factor In Beta-thalassemia

Objective The levels of plasma soluble E-selectin(sE-sel)、 vonwillebrand factor（vWF）、 tissue factor（TF）、tissue factor pathway inhibitor（TFPI）、thrombin-antithrombin Ⅲ complex（TAT）and platelet count（PLT）in β-Thalassemia patients were measured, and to explore the presence ofactivation and damage of endothelial cells,the imbalance of TF and TFPI,and theprethrombotic state in β-thalassemia patients of the Guangxi Province China.Methods32β-Thalassemia patients and10health were selected intothe study.The levels of plasma sE-sel,vWF、TF、TFPI and TAT were measuredby ELISA assay. The platelet count was detected by Automatic hematologyAnalyzer.Results1、The PLT of β-thalassemia intermedia splenectomy groupand β-thalassemia major splenectomy group were higher than normal values andwere significant higher than the normal control group. The PLT of β-thalassemiaintermedia non-splenectomy group was in the normal range,and was no difference with the normal control group;2、Compared with normal control group,the level of sE-sel was elevatedin β-thalassemia intermedia splenectomy group、 β-thalassemia intermedianon-splenectomy group and β-thalassemia major splenectomy group.The levelof sE-sel in β-thalassemia intermedia splenectomy group was significantlyhigher than β-thalassemia intermedia non-splenectomy group or β-thalassemiamajor splenectomy group;3、The levels of vWF、TF、TFPI and TAT in β-thalassemia intermediasplenectomy group、 β-thalassemia intermedia non-splenectomy group andβ-thalassemia major splenectomy group patients were in the normal range,andwere no difference with the normal control group;4、In β-Thalassemia patients,sE-sel was positive correlated with TFPIand PLT. Splenectomy was positive correlated with PLT.Conclusion β-thalassemia patients may presence vascular endothelialcell activation and damage, especially in β-thalassemia intermedia splenectomypatients with occasional blood transfusions. The platelet count continuouslyelevated in splenectomy β-thalassemia patients. Endothelial cell activation andthe platelet counts continuously elevating may increase the risk ofthromboembolism in patients with β-thalassemia.