¹⁸F-FDG PET/CT In Diagnose And Treatment Of Non Hodgkin’s Lymphoma

Background and objective：Currently, PET/CT is the only one equipment that combines bothanatomical imaging and metabolic imaging. PET/CT has the advantagesof high sensitivity, high specificity of inspection for lymphoma. But18F-FDG has its limitations, the evaluation of lymphoma in installment andinvasive judgment still needs further validation. This study takes theadvantage of18F-FDG PET/CT’feature which can reflect and organizingboth anatomical and functional features of the metabolic state, discusses18F-FDG PET/CT in the diagnosis of non-Hodgkin’s lymphoma instaging, assessment of curative effect, the value in non-invasive NHL andto provide clinical research data for clinic doctors.Materials and Methods：This study were retrospectively analyzed the data of103patientswith non-Hodgkin’s lymphoma（NHL） from2011April1to April1,2014in Jilin university Bethune first hospital，those patients were alldiagnosed NHL by surgical removal or local puncture biopsy and didPET/CT. This study evaluated the use of PET/CT detecting lymphoma involvement, to the distribution of the compared with traditionalinspection method for evaluation value of lymphoma in stages, andassessment the value of PET/CT in NHL curative effect。Discuss the SUVvalues, LDH, β2-micro globulin (β2-MG) and Ki-67with thecorrelation of tumor invasive. This study analyzed the value of PET/CTin NHL’s clinic staging，assessment of curative effect、the value ofPET/CT in non-invasive NHL。Results：1,18F-FDG PET/CT compared with CT for the detection oflymphoid tissue and organ lesions consistent rate is95%, and for thedetection of extranodal lesions consistent rate is54.9%. PET/CT for thesoft tissue, bone and gastrointestinal lesion detection advantage than CT.But for the bone marrow lesion detection rate is lower than thecytological examination of bone marrow.2, First through the CT, MRI, superficial tissue ultrasound and bonethrough routine inspection of the stage, and then combined with PET/CTexamination results again stage, comparing the two stage results,consistent rate of two up to69%, and caused up regulation of PET/CTstaging was mainly due to soft tissue, bone lesion detection rate is higherthan that of CT examination by stages, reduction was mainly due toPET/CT for non neoplastic causes lymph node or spleen increaseddiscrimination than CT examination. 3, LDH (p=0.166), β2-MG (p=0.134) of aggressive and inert NHLhad no statistically significant differences in the level of. InvasiveSUVmax (p=0.000), the positive rate of Ki-67(p=0.000) is higher thanthat of inert, the difference was statistically significant (p=0.000). theSUVmax and Ki-67correlation coefficient of0.875, two had positivecorrelation.4, Total32cases underwent PET/CT in patients followed up for3-24months, PET/CT-negative recurrence rate is16.7%, positiverecurrence rate is57.1%, Fisher’s exact test p=0.027, the difference wassignificant.17cases of intermediate PET/CT results showed:7cases ofCR, were followed up for8-24months (average14.6months) for CR.10cases showed SUVmax high uptake, with an average value of7.91(2.6-15.5).10cases in6cases of the middle PET/CT SUVmax with anaverage value of4.32(2.6-8.3), after adjustment for treatment of CR,follow-up8-24months (average12.3months) for CR. More than4casesof the middle PET/CT SUVmax with an average value of13.3(10.5-15.5), the disease progresses, the chemotherapy effect difference.5, the24cases were indolent lymphoma, but PET/CT SUVmax high,SUVmax is in the range of5.3-20.5(average11.9, median11.5), with aninert NHL standard after4course of treatment was used to evaluate thecurative effect and only1patients achieved CR, and strengthening in the4period of treatment of20cases of re evaluation based on2-4after a course of treatment (83.3%) to CR.Conclusion：1,18F-FDG PET/CT improve the detection rate of lesions of NHL,especially for diffuse non-mass type lesions，such as bone and soft tissue,PET/CT is good for accurate staging.2, SUVmax and Ki-67positive rates of invasive NHL is higher thanthe inert NHL, SUVmax and Ki-67positive rates were positivelycorrelated.3, PET/CT evaluation of post-therapy of NHL，recurrence rate ofpositive PET/CT is high and negative prognosis is good.4, Indolent lymphoma, high SUVmax, likely to prompt aggressivetransformation, treatment should be made as aggressive NHL.