The Influence Of Smoking On Chronic Obstructive Pulmonary Disease

Objective:By comparing the smoking group and non-smoking group of COPDpatients from age, the degree of lung function impairment, treatment ofpulmonary function improvement rate and the relationship between smokingindex and pulmonary function,to seek the influence of smoking on COPD.Methods:Medical records for260patients hospitalized at the First Clinical Hospitalof Jilin University between January2013and December2013and who aretested by the pulmonary function test and diagnosed for the acute exacerbationchronic obstructive pulmonary disease.According to whether there is a smokinghistory, divided into smoking group and non-smoking group of COPD.Including140patients with smoking and120non-smoking patients of COPD. All thepatients are calculated the average age of smoking and non-smoking group;According to the standard classification of COPD, the two groups werestatistical the number of patients constituted of mild, moderate, severe, verysevere group;the correlation analysis between Smoking index and lung function;To compare the lung function of ventilation（FEV1%pred, FVC%pred, FEV1／FVC%pred）,volume（RV%pred, TLC%pred, RV/TLC%pred）,diffusion（DLCO%pred）and small airway（PEF%pred, MMEF75/25%pred）of smokingand non-smoking. Pulmonary function was graded as severe patients receivedconventional therapy such as oxygen inhalation, anti-inflammation,relieving cough, reducing sputum and antispasmodic for5days.And then do the pulmonary function tests again to compare the improvement rate ofsmoking group and non-smoking group.Results:1.Compared with nonsmoking group, when the course of disease thereare no difference between smoking group (P>0.05), the age less thannonsmoking patients significantly(P <0.05).2.Smoking group with severe and extremely severe higher proportion,and non-smoking group with mild and moderate groups higher proportion,two groups of constituent ratio was statistical significantly (P <0.05).3.Smoking group COPD patients, the heavier lung function grade, thehigher the smoking index (p <0.05); Based on smoking indexclassification,there groups is different in consisting of pulmonaryfunction index of smoking(P <0.05), smoking index and lung functiongrading linear trend, pulmonary function level with smoking indexincreased (P <0.017); there was a negative correlation between smokingindex,such as FEV1%pred, FVC%pred, FEV1/FVC%pred,TLC%pred,DLCO%pred, PEF%pred, MMEF75/25%pred (P <0.05); RV%pred andRV/TLC%pred was positively correlated (P <0.05).4.Comparing with the non-smoking group, smoking group ofpulmonary function in FEV1%pred, FVC%pred, FEV1/FVC%pred,TLC%pred, DLCO%pred, PEF%pred, MMEF75/25%pred decreasedsignificantly(P <0.05).And RV%pred, RV/TLC%pred than non-smokinggroup increased obviously(P <0.05).5.Comparing with the non-smoking group, severe COPD patients aftertreatment, smoking group pulmonary function improvement rate wassignificantly lower than non-smoking group, the difference was statisticalsignificantly (P <0.05). Conclusion:1.Smoking in patients with COPD pathogenesis average age earlierthan nonsmoking patients.2.Smoking patients with COPD is easy to develop the severe or verysevere COPD.3.The more smoke,the worse lung function than non-smokinggroup,including ventilation,volume,diffusion and small airway.4.Smoking of COPD patients is lower in treatment sensitivity thannonsmoking patients.