Study On Brain MRI Scan And Clinical Features In NMO

Objective：1.To study the brain MRI abnormalities of neuromyelitis optica（NMO）patients；2.To analyze the clinical features between brain MRI abnormal team and brainMRI normal ones.Materails and method：1.We retrospectively registered the NMO cases admitted to the Neurologydepartment in the Norman Bethune1st Hospital of Jilin University during December2012to January2013, and collected the epidemiologic features、presentations、EDSSscores、laboratory data、MRI features1Group definition2.We collected Clinical data of40cases NMO patients meeting Wingerchuk’Snew diagnosis criteria, Two groups: brain MRI abnormal group and brain MRInormal group.3.We used SPSS17.0software for statistical analysis: Measurement data with theGaussian distribution using t test, measurement data without the Gaussiandistribution using Mann-Whitney U test, and enumeration data using2test.Wilcoxon rank sum tests were used to assess differences between groups when thedistribution is skew. A significant level of P<0.05was consider.Results：1.Abnormal brain MRI performed in40NMO patients21cases (52.50%) werefound to have abnormal signals on brain MRI, subcortical, pulp border area7cases(33.33%); Near ventricle10cases (47.62%); Occurred in Basal ganglia region6cases(28.57%);9cases (42.86%) in brainstem.2.There were significant differences between the two groups in episodes EDSSand autoimmune diseases exist (P <005), and There were no significant difference inage, sex, disease relapse, cerebrospinal fluid examination, NMO-IgG, spinal MRIlesions distribution (P>0.05).Conclusion: 1.There was high brain abnormality rate in NMO;2.Abnormal head MRI group, has a higher episodes EDSS, more withautoimmune diseases.