The Preparation Methods Of Profit Liver Ⅱ Particle Number Research And Quality Control

Objective: through the traditional decoction method in clinical experience for effective preparation technique and quality control research.Methods:Israel in qualitative analysis, thin layer identification of each drug and prescription of the gentleman medicine astragalus armour of astragalus glycosides as the index to carry on the quantitative research, with orthogonal test and water decoction method, water and extraction times (time) to profit liver II size particles preparation factors on the optimal selection. And through all kinds of excipients and the concentration of ethanol as a wetting agent, in order to achieve the best dosage form in the preparation of the finished granules.Results:through the thin layer identification of various kinds of into the identification, detection and bring them one by one, confirmed that the qualitative analysis of the effect is very good; Examples using the HPLC-ELSD method for determining the content of astragalus astragalus armour glycosides in practical, in process by orthogonal test analysis, we chose to12times eight times, ten times, water decoction extract three times, time for each0.51.5h,1h, h, finally get the best technology for using8times of water, each decoction1.5h had highest dry ointment yield, extracting3times, and used in the process of preparation of starch mixture with a ratio of2:1cyclodextrin as excipient, easy granulating, particles made of good appearance, hygroscopicity, conform to the requirements of the preparation. In the aspect of wetting agent is obtained through the experiment to80%ethanol as the best concentration of wetting agent. In a series of preparation process conditions for the final test results:the main drugs:excipient=1-0.8,1.5%protein, sugar,80%alcohol as the wetting agent granulating, drying, granulation, partial shipments for a quick.Conclusion:Yi liver II particle number technique is reasonable, quality control, stable formulations.