| Objective: Chronic heart failure in a complex clinical syndrome, is theserious stage of various heart disease, its occurrence and development ofpathophysiological mechanisms of cardiac remodeling, and neuroendocrineexcited for a long time and excessive secretion is the leading cause ofmyocardial remodeling.Has proved the serum b-type natriuretic peptide (BNP)level was positively correlated with the severity of heart failure, in recentyears have reported serum carbohydrate antigen125(CA125) level changesassociated with hemodynamic and clinical symptoms in patients with heartfailure. This research through the determination of CHF patients withperipheral blood CA125and the correlation of BNP and cardiac functionclassification.Methods: Collection includes between January2013and December2013in the second hospital, hebei medical university heart was in the hospital withclear diagnosis of173cases of patients with chronic heart failure, amongwhich104were male, female69cases, age59.69+/-59.69. Record selectedpatients: gender, age, past medical history, routine blood, myocardial enzymes,troponin, blood lipid, blood glucose, serum BNP value, ejection fraction andHeart function classification, etc., cardiac function according to the New YorkHeart Association (New York Heart Association, NYHA) standardassessment.All patients admitted to hospital after extraction of venous blood3ml, determination of the BNP, CA125values, according to the hospital at thattime routine via chest cardiac color doppler echocardiography, recorded inpatients with left ventricular ejection fraction (LVEF). After admission ofpatients according to the treatment of chronic heart failure treatmentguidelines, the use of angiotensin converting enzyme inhibitors (ACEI) orangiotensin Ⅱreceptor antagonist (ARB), beta blockers, diuretic, cardiac,expanding blood vessels such as drug therapy.40patients after the treatment of5-20days, got better after the review of the serum CA125. Using SPSSstatistical analysis software, version17.0measurement data to mean+/-standard deviation （X S）; Count data using percentage said. Each packetdata to normality and f test. If accord with normal distribution, the comparisonbetween the two groups choose independent sample t-test; Otherwise thenonparametric test for statistical analysis. Group patients before and aftertreatment comparison for paired samples t test, CA125is associated with theBNP and left ventricular ejection fraction analysis using Pearson correlationanalysis, P <0.05think the difference was statistically significant.Results:1The general situationThe control group,30cases of patients with an average age of54.33+/-6.48years old,18cases of men, women,12cases;37patients with NYHA Ⅱlevel,21.38%of the total number of patients with heart failure, average age58.68+/-11.24,21cases of men, women,16cases;68patients with NYHAⅢlevel,39.31%of the total number of patients with heart failure, the averageage of59.93+/-12.51years old,40cases of men, women,28cases;68patients with NYHA Ⅳlevel,39.31%of the total number of patients withheart failure, the average age of60.36+/-10.58years old,43cases of men,women,25cases.2The serum CA125levelThe control serum CA125level was7.99+/-5.87U/ml, hospital cardiacfunction Ⅱ level group was9.85+/-4.80U/ml, cardiac function Ⅲlevelgroup was41.98+/-19.55U/ml, cardiac function level IV group was157.97+/-89.16U/ml. Grade of cardiac function Ⅱgroup compared with controlgroup, there was no statistically significant difference (P=0.158>0.05),cardiac function Ⅲ level group, the cardiacfunction level IV group comparedwith control group, serum CA125levels were higher, the difference wasstatistically significant (P <0.05); Cardiac function level IV, cardiac Ⅲgroupcompared with cardiac Ⅱgroup, serum CA125levels were significantlyelevated, there is significant statistical difference (P <0.05); Cardiac function level IV group compared with cardiac Ⅲlevel group, serum CA125levelincreased, the difference was statistically significant (P <0.05).3The cardiac function before and after improving serum CA125level ofpatients with chronic heart failureWith patients before treatment the serum CA125level was169.98+/-73.71U/ml. Patients after treatment the serum CA125level was76.06+/-53.06U/ml. After treatment compared with before treatment in patients withsignificantly lower serum CA125level, there are significant statisticaldifference (P <0.05).4The level of CA125and BNP level and left ventricular ejection fraction(LVEF) correlation analysisSerum CA125level and BNP concentrations were positively correlated (r=0.805, P <0.05).Serum CA125level and LVEF (%) showed a negative correlation (r=0.-758, P <0.05).Conclusion:1serum CA125level is associated with the severity of heart failure,cardiac function classification, the higher the patients, the higher the level ofserum CA125.2patients with heart failure after hospitalization, serum CA125level dropbefore treatment.3the serum CA125level with the increase of the BNP, both werepositively correlated.4serum CA125level with left ventricular ejection fraction LVEF (%)decreased, a negative correlation. |
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