The Clinical Observation Of Zi Nifuzheng’ Anshen Prescription In Treating Postoperative Breast Cancer Patients With Insomnia

Insomnia is a common disease for the postoperative breast cancer patients, which seriously affected their quality of life, caused the endocrine disorder and weakened immune system, assisted to the metastasis and recurrence of tumors and was not conducive to the rehabilitation of the breast cancer patients after operation. At present,the sedative-hypnotic drugs are often used in the modern medicine to treat breast cancer postoperative insomnia. Although it has a good short-term curative effect, it is easy to repeat and has side effects, like tolerance and addiction after long-term use.The physical condition of the postoperative breast cancer patients is very complex. In this case, the Chinese traditional medicine has the characteristics of being integrated and dialectic unification. It can use drugs to nurse the patients’health according to their present state of qi, Yin and Yang, combining the treatment for insomnia and post operative rehabilitation together. With respect to the sedative-hypnotic drugs treatment, the curative effect of Chinese traditional medicine is more enduring and without obvious side effects, reflecting its advantage. My mentor professor Wang zheming find out that breast cancer postoperative insomnia is often caused by deficiency of spleen and kidney and lack of spirit preservation. Professor Wang has concluded the Zi Nifuzheng’anshen Prescription(self-made prescription for strengthening the body resistance and calming the nerves)to treat this kind of insomnia during the long-term clinical treatment of tumor. Its curative effect is significant and enduring. Since this therapy was not popularized and observed systematically, so this topic will observe and study on it by applying the experiment design method of randomized control trail.Research purposeTo observe objectively and to evaluate the near future curative effect and clinical advantages of ZZi Nifuzheng’anshen Prescription (self-made prescription for strengthening the body resistance and calming the nerves) for insomnia treatment of post operative patients with breast cancerResearch methods To divide the66qualified patients randomly divided into two groups by draw. The experimental group A includes33cases, The experimental group B33cases and number every case. The experimental group A take Zi Nifuzheng’anshen Prescription twice a day for two courses which contain14days, the contrast group B take estazolam tablets, one tablet each time before going to bed once a day for two courses which contain14days, to keep an account of the observation indexes three times respectively on the day of first treatment, two weeks after treatment and one month later the two courses. Observe curative effect by Pittsburgh sleep quality index (PSQI), record score in both groups, and evaluate the difference between the two grou, census the before and after treatment statistical data by SPSS19.0The results of the study:1. The total effective rate of group A taking Zi Nifuzheng’anshen Prescription is81.25%while the total effective rate of group B taking estazolam tablets is90.00%. There is no significant statistical difference between the two groups calculated by Fisher’s Exact probability method, Fisher’s Exact Test=3.91, P=0.28>0.05.2. Differential between the composition of PSQI scores and kps scores of the two groups is of no obvious statistical difference checking up by PSQI total scores, composition A sleep quality, C sleeping time, D sleep efficiency and G daytime dysfunction P>0.05. The above data illustrates that there is no different improving effect between the two groups, composition B sleeping time, E sleep disorder and kps scores are P<0.05, there is obvious statistical difference. Accordingly, group B has an advantage in improving the sleeping time and sleeping disorder of the patients over group A and group A is better in improving kps scores than group B.3. The comparison of the two groups their own before and after treatment one month later is of no statistical difference, examined by the Wilcoxon E sleep disorders and F hypnotic of group A both P>0.05, suggesting that group A is of no statistical difference before and after treatment. There is no difference of group B in E sleeping disorder, F hypnotic index, and kps scores p> o. o5, saying no obvious improvement in sleeping disorder hypnotic and kps scores while the rest are bettering.4. The comparison between the two groups one month after treatment is no obvious statistical difference, the composition of PSQI scores and and the kps score difference between the two groups through the t test, PSQI scores, G daytime dysfunction were P>0.05. That is to say, group A and group B in the treatment of the above two aspects have no obvious difference. B Sleep time P is0.044<0.05with a statistically significant difference,showing that after the treatment of a month, the sleeping time improvement of group A is better than group B.the composition of PSQI A sleep quality,C sleep time,D sleep efficiency, G daytime dysfunction and KPS scores are less than0.01.The.difference is extremely obvious,indicating that group A is better than group B in the improvement in these aspects.5.Thepatients are of no obvious discomfort in the process of the whole experiment, except one loss in group A and3cases of loss in group B.Research conclusions:1.Zi Nifuzheng’anshen Prescription is effective for insomnlia of postoperative breast cancer patients;2.Zi Nifuzheng’ anshen Prescriptlion is better for treating insomnia of postoperative breast cancer patients than sedative hypnotics in long—term clinical effect.3.Zi Nifuzheng’ anshen Prescription is of great security for treating insomnia of postoperative breast cancer patients.