Cardiac And Renal Hemodynamic Changes In Endotoxic Rabbits Detected By High-frequency Ultrasound

Objectives: To dynamically observe cardiac and renal hemodynamicchanges in different dosage of endotoxin rabbits with high-frequencyultrasound.Methods:25healthy adult male New Zealand white rabbits wererandomly assigned to a normal saline group(n=5),5μg/kg endotoxin group(n=10) or500μg/kg endotoxin group(n=10). Endotoxemia model was built bysingle intravenous injection of lipopolysaccharide（LPS）. Before injection ofsalin/LPS and1,2,3,4,5,6h after injection, vital signs (heart rate, bloodpressure,respiratory rate and temperature) were recorded, cardiachemodynamics indexe（sLVEF, LVFS, LVPWd, LVPWs, IVSd, IVSs, LVIDd,SV,CO, MV VEmaxand AV Vmax）and renal hemodynamics indexe（sPSV, EDV,RI,PI）were monitorted by high-frequency ultrasound.. At the timepoint of6-hour after injection, all rabbits were sacrificed.Results: There were significant differences (P<0.05) in the vital signs,cardiac and renal hemodynamical changes among the saline group, the5μg/kgendotoxin group and the500μg/kg endotoxin group. Survival rates among thethree groups were not statistically different (P>0.05).Conculsion: There are significant differences in vital signs, cardiac andrenal hemodynamic changes in different doses of endotoxin group. Theirhemodynamic changes are directly related to the dose of LPS.